82455-07-0

Basic information

• Product Name: (2E)-6-fluoro-1H-indene-1,2(3H)-dione 2-oxime
• CAS NO: 82455-07-0
• Molecular Formula: C₉H₆FNO₂
• Molecular Weight: 179.1478
• Mol File: 82455-07-0.mol

Chemical Properties

• Boiling Point: 347°C at 760 mmHg
• Flash Point: 163.7°C
• Density: 1.46g/cm³
• Vapor Pressure: 2.09E-05mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: (2E)-6-fluoro-1H-indene-1,2(3H)-dione 2-oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-6-fluoro-1H-indene-1,2(3H)-dione 2-oxime(82455-07-0)
• EPA Substance Registry System: (2E)-6-fluoro-1H-indene-1,2(3H)-dione 2-oxime(82455-07-0)

Safety Data

• Hazardous Substances Data: 82455-07-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(2E)-6-fluoro-1H-indene-1,2(3H)-dione 2-oxime is used as a key intermediate in the synthesis of diverse classes of biologically active compounds. Its oxime functionality and fluoroindene core provide specific properties and interactions that are valuable in the design and development of therapeutic agents.
Used in Medicinal Chemistry:
(2E)-6-fluoro-1H-indene-1,2(3H)-dione 2-oxime is utilized as a versatile chemical entity in medicinal chemistry. It serves as a valuable tool for studying structure-activity relationships of bioactive molecules, contributing to the discovery of new drugs with improved efficacy and selectivity.
Used in Organic Chemistry:
As a building block in organic chemistry, (2E)-6-fluoro-1H-indene-1,2(3H)-dione 2-oxime is employed for the preparation of a wide range of compounds with potential applications in various fields, including materials science, agrochemicals, and specialty chemicals.

Upstream product

• 1481-32-9 6-fluoroindan-1-one 
• 544-16-1 n-Butyl nitrite 
• 109-86-4 2-methoxy-ethanol 

Downstream Products

• 941294-25-3 1,3-dichloro-7-fluoroisoquinoline 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Catalytic Asymmetric Mannich/Cyclization of 2-Isothiocyanato-1-indanones: An Approach to the Synthesis of Bispirocyclic Indanone-Thioimidazolidine-Oxindoles

This study demonstrates that novel isothiocyanates derived from 1-indanones are useful building blocks in heteroannulation reactions with isatinimines. This convenient Mannich/cyclization cascade reaction serves as a powerful tool for the enantioselective construction of bispirocyclic indanone-thioimidazolidine-oxindoles bearing two adjacent spiro-quaternary stereocenters in good to excellent yields with excellent diastereo- and enantioselectivities. Versatile transformations of the products into other potential bioactive bispirocyclic heterocycles have also been demonstrated.

Indan-1-ol compounds

A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be identical or different, represent hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, trihaloalkyl, or any pair may form a heterocycle, R5 represents hydrogen

Herbicidal isoquinolinoxy- or isoquinolinamino-phenoxy alkane carboxylic acid derivatives

The invention concerns novel compounds of the formula I STR1 The compounds are herbicides and in further embodiments the invention provides: processes for the preparation of compounds of formula I; intermediates useful in the preparation of compounds of formula I; compositions containing as active ingredient compounds of formula I; and processes for severely damaging or killing unwanted plants by applying to the plants or to the growth medium of the plants an effective amount of a compound of formula I.