82460-32-0Relevant academic research and scientific papers
Synthesis of [trifluoromethyl-[14C6]-phenyl]- SR 57746A
Robic,Noel
, p. 109 - 119 (2007/10/03)
[Trifluoromethyl-[14C6]-phenyl]- SR 57746A 4, a neurotrophic and neuroprotective compound, has been synthesized for metabolic and pharmacokinetic studies. The key step for its synthesis was the preparation of 3-trifluoromethyl-[14C6]-bromobenzene 1. This compound was obtained in 4 steps from [14C6]-nitrobenzene 10 via [14C6]-3-iodo-nitrobenzene 11, 3-trifluoromethyl-[14C6]-nitrobenzene 8, 3-trifluoromethyl-[14C6]-aniline 9. The overall yield for the 4 steps was 35%, the specific activity was 29 mCi/mmol and the radioactive purity was better than 98%. The Grignard reagent of 1 gave the title compound after condensation with N-(2-naphthylethyl)-4-piperidone 12 and dehydration.
