82463-33-0Relevant academic research and scientific papers
NIXANTPHOS: A highly active ligand for palladium catalyzed Buchwald-Hartwig amination of unactivated aryl chlorides
Mao, Jianyou,Zhang, Jiadi,Zhang, Shuguang,Walsh, Patrick J.
, p. 8690 - 8696 (2018)
Xantphos is one of the two most common ligands used in palladium catalyzed Buchwald-Hartwig amination reactions, because of its broad scope and high probability of success. It does not, however, work well with unactivated aryl chlorides. Herein NIXANTPHOS is compared to Xantphos and an array of mono- and bidentate phosphines. NIXANTPHOS outperforms Xantphos and all other bidentate ligands examined. Under the optimal reaction conditions, unactivated aryl chlorides afford the expected products in good to excellent yield with as low as 0.05 mol% (500 ppm) palladium loading.
A new efficient palladium catalyst for the amination of aryl chlorides
Nettekoven, Ulrike,Naud, Frédéric,Schnyder, Anita,Blaser, Hans-Ulrich
, p. 2549 - 2552 (2007/10/03)
A highly active catalyst for the Buchwald-Hartwig amination has been developed. The new catalyst, a combination of a dimethylaminomethyl ferrocene palladacycle and bis(2-nor-bornyl)phosphine shows high activity and broad scope for the coupling of non- or deactivated aryl chlorides with primary and secondary amines as well as (hindered) anilines.
