82467-52-5

Basic information

• Product Name: Isokadsuranin
• Synonyms: Isokadsuranin
• CAS NO: 82467-52-5
• Molecular Formula: C₂₃H₂₈O₆
• Molecular Weight: 400.46482
• Mol File: 82467-52-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 545°Cat760mmHg
• Flash Point: 220.4°C
• Appearance: /
• Density: 1.148g/cm³
• CAS DataBase Reference: Isokadsuranin(CAS DataBase Reference)
• NIST Chemistry Reference: Isokadsuranin(82467-52-5)
• EPA Substance Registry System: Isokadsuranin(82467-52-5)

Safety Data

• Hazardous Substances Data: 82467-52-5(Hazardous Substances Data)

Usage

Description

Isokadsuranin is a Schisandrin B enantiomer found in rat plasma, characterized by its multiple pharmacological properties.

Uses

Used in Pharmaceutical Industry:
Isokadsuranin is used as a pharmaceutical agent for its diverse pharmacological properties, which include potential applications in various therapeutic areas.
Used in Drug Development:
Isokadsuranin is utilized in drug development as a compound with multiple pharmacological properties, offering a promising foundation for the creation of new medications targeting a range of health conditions.

Upstream product

• 58546-54-6 gomisin A 
• 62555-46-8 C₂₃H₂₆O₆ 
• 82425-43-2 (-)-gomisin L₁ 
• 77-78-1 dimethyl sulfate 
• 82425-44-3 (-)-gomisin L₂ 
• 82425-45-4 (+)-gomisin M₂ 
• 82425-46-5 C₂₄H₂₈O₇ 
• 148812-34-4 (3aRS,SR-Biar)-3a,4-dihydro-8,9,10,11-tetramethoxy-6,7-(methylenedioxy)dibenzo<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one 
• 82425-43-2 (+/-)-gomisin M₁ 
• 161906-44-1 (R)-(E)-3-(3,4,5-trimethoxybenzyl)-2-(3,4-methylenedioxy-5-methoxy)butyrolactone 
• 76763-88-7 (R)-dihydro-4-(3,4,5-trimethoxybenzyl)furan-2(3H)-one 
• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 

Downstream Products

• 61281-38-7 (-)-deoxyschizandrin 
• 64121-95-5 gomisin N 
• 64121-95-5 (+)-γ-schizandrin 

Relevant articles and documents

Biotransformation of isofraxetin-6-O-β-D-glucopyranoside by Angelica sinensis (Oliv.) Diels callus

Isofraxetin-6-O-β-D-glucopyranoside, identified from traditional medicinal herbal Xanthoceras sorbifolia Bunge, has been demonstrated to be a natural neuroinflammatory inhibitor. In order to obtain more derivatives with potential anti-neuroinflammatory effects, biotransformation was carried out. According to the characteristics of coumarin skeleton, suspension cultures of Angelica sinensis (Oliv.) Diels callus (A. sinensis callus) were employed because of the presence of diverse phenylpropanoids biosynthetic enzymes. As a result, 15 products were yielded from the suspension cultures, including a new coumarin: 8′-dehydroxymethyl cleomiscosin A (1), together with 14 known compounds. Their structures were elucidated by extensive spectroscopic analysis. Furthermore, the biotransformed pathways were discussed. Among them, compound 13 was transformed from isofraxetin-6-O-β-D-glucopyranoside, while compounds 1–6, 10–12, 14–15 were derived from the culture medium stimulated by the substrate. The biotransformation processes include hydroxylation, oxidation and esterification. Furthermore, their inhibitory effects on lipopolysaccharide (LPS)-activated nitric oxide (NO) production were evaluated in BV2 microglial cells. It is worth noting that, 1, 1′-methanediylbis(4-methoxybenzene) (3), obtucarbamates A (5), 2-nonyl-4-hydroxyquinoline N-oxide (10) and 1H-indole-3-carbaldehyde (11) exhibited significant inhibitory effect against neuroinflammation with IC50values at 1.22, 10.57, 1.02 and 0.76?μM respectively, much stronger than that of the positive control minocycline (IC5035.82?μM).

Kadsulignans L-N, three dibenzocyclooctadiene lignans from Kadsura coccinea

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The constituents of Schizandra chinensis BAILL. X. The structures of γ-schizandrin and four new lignans, (-)-gomisins L1 and L2, (±)-gomisin M1 and (+)-gomisin M2

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