82472-39-7Relevant academic research and scientific papers
Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives
Li,Black,Chan,Ford-Hutchinson,Gauthier,Gordon,Guay,Kargman,Lau,Mancini,Ouimet,Roy,Vickers,Wong,Young,Zamboni,Prasit
, p. 4897 - 4905 (2007/10/03)
The recent discovery of an alternative form cyclooxygenase (cyclooxygenase-2, COX-2), which has been proposed to play a significant role in inflammatory conditions, may provide an opportunity to develop anti- inflammatory drugs with fewer side effects tha
Non-steroidal antiinflammatory agents. Part VII. Methane sulfonanilides
Schroeder,Lehmann,Rufer,Bottcher
, p. 165 - 172 (2007/10/02)
Synthesis and antiinflammatory activity (rat) of indane derivatives related to the potent antiinflammatory N-(6-phenoxy-5-indanyl) methane sulfonamide are described. The following structure activity relationships can be recognized. Replacement of the O atom of the phenoxy residue by a direct bond, a (substituted) methylene or a carbonyl group only in the latter case led to active compounds. In general, modification of the methane sulfonamide moiety resulted in loss of activity, however, the chloro- and fluoro-methanesulfonamides, as well as the N-acetyl methanesulfonamide proved to be active. When the phenyl ring was replaced by cyclohexyl, naphthyl or heterocyclic ring systems, activities were found only in the pyridyloxy derivatives
