82490-77-5Relevant academic research and scientific papers
Silver-catalyzed intramolecular aminofluorination of activated allenes
Xu, Tao,Mu, Xin,Peng, Haihui,Liu, Guosheng
supporting information; experimental part, p. 8176 - 8179 (2011/10/09)
A nice combination: The intramolecular oxidative aminofluorination of allenes using silver catalysis and FN(SO2Ph)2 as the fluorinating reagent has been developed. This reaction represents an efficient method for the synthesis of various 4-fluoro-2,5-dihydropyrrole compounds. Further transformation provided the corresponding fluorinated pyrrole derivatives in good yields (see scheme).
A versatile synthetic platform based on strained propargyl amines
He, Zhi,Yudin, Andrei K.
, p. 1607 - 1610 (2010/06/16)
"Chemical Equation Presented" Divergent reactivity: Various ethynylaziridines behave as strained propargyl amines and can be directly converted into unprotected α-amino allenes by a highly diastereoselective SN2′ hydride delivery (see scheme). Additional reaction routes involve chemo- and regioselective transformation into either bicyclic aziridine/ enol ethers or highly strained azirine alkynes.
INHIBITORS OF LYSYL OXIDASE
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, (2008/06/13)
This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
A FACILE SYNTHESIS OF β-SUBSTITUTED -α-ALLENYL PRIMARY AMINES
McCarthy, James R.,Barney, Charlotte L.,Matthews, Donald P.,Bargar, Thomas M.
, p. 2207 - 2210 (2007/10/02)
Copper or nickel catalyzed substitution of Grignard reagents on the bis-trimethylsilyl protected 4-methoxy-2-butynylamine (2) provides β-substituted-α-allenyl primary amines (3) in high yield.
