824976-18-3Relevant academic research and scientific papers
Synthesis and biological activity of fluorinated combretastatin analogues
Alloatti, Domenico,Giannini, Giuseppe,Cabri, Walter,Lustrati, Isabella,Marzi, Mauro,Ciacci, Andrea,Gallo, Grazia,Tinti, M. Ornella,Marcellini, Marcella,Riccioni, Teresa,Guglielmi, Mario B.,Carminati, Paolo,Pisano, Claudio
, p. 2708 - 2721 (2008/12/22)
With the aim of understanding the influence of fluorine on the double bond of the cis-stilbene moiety of combretastatin derivatives and encouraged by a preliminary molecular modeling study showing a different biological environment on the interaction site
FLUOROCOMBRETASTATIN AND DERIVATIVES THEREOF
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Page/Page column 22; 6-6, (2008/06/13)
The present invention is related to new derivatives of Combretastatin, of Formula (I) obtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on olefinic bound; ii) replace
