824976-22-9Relevant academic research and scientific papers
Reagent for preparing high-selectivity monofluoroolefin
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Paragraph 0327-0329; 0332; 0333, (2021/09/04)
The invention provides a reagent for preparing high-selectivity monofluoroolefin, particularly a reagent capable of preparing monofluoroolefin at high selectivity and a method for preparing monofluoroolefin by using the reagent. The method has the advanta
Spontaneous resolution of julia-kocienski intermediates facilitates phase separation to produce Z - And e -monofluoroalkenes
Zhao, Yanchuan,Jiang, Fanzhou,Hu, Jinbo
, p. 5199 - 5203 (2015/05/05)
The monofluoroalkene motif is important in drug development as it serves as a peptide bond isostere and is found in a number of biologically active compounds with various pharmacological activities. Direct olefination of carbonyl compound is a straightfor
Synthesis and biological activity of fluorinated combretastatin analogues
Alloatti, Domenico,Giannini, Giuseppe,Cabri, Walter,Lustrati, Isabella,Marzi, Mauro,Ciacci, Andrea,Gallo, Grazia,Tinti, M. Ornella,Marcellini, Marcella,Riccioni, Teresa,Guglielmi, Mario B.,Carminati, Paolo,Pisano, Claudio
, p. 2708 - 2721 (2008/12/22)
With the aim of understanding the influence of fluorine on the double bond of the cis-stilbene moiety of combretastatin derivatives and encouraged by a preliminary molecular modeling study showing a different biological environment on the interaction site
