824982-18-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(8-benzyl-3,8-diaza-bicyclo[3.2.1]octan-3-yl)-2,2,2-trifluoroethanone is used as a valuable intermediate for the development of novel drugs due to its unique chemical properties and reactivity.
Used in Organic Synthesis:
1-(8-benzyl-3,8-diaza-bicyclo[3.2.1]octan-3-yl)-2,2,2-trifluoroethanone is used as a versatile building block for the synthesis of complex organic molecules, particularly in the development of advanced materials.
Used in Organic Transformations and Synthetic Methodologies:
1-(8-benzyl-3,8-diaza-bicyclo[3.2.1]octan-3-yl)-2,2,2-trifluoroethanone is used as a versatile reagent in organic transformations and synthetic methodologies, thanks to its trifluoroethyl ketone moiety.

Upstream product

• 93428-56-9 8-benzyl-3,8-diazabicyclo[3.2.1]octane 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 824982-19-6 tert-butyl 3-(2,2,2-trifluoroacetyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate 

Relevant academic research and scientific papers

Substituted diazabicycloakane derivatives

Compounds of formula (I) Z-Ar1—Ar2??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

Novel amides useful for treating pain

The present invention relates to compounds of formula (I) that useful in treating pain.

Novel amides useful for treating pain

The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.