82499-20-5

Basic information

• Product Name: (1R)-1-hydroxy-1-(3-hydroxyphenyl)propan-2-one
• Synonyms: 82499-20-5;(1R)-1-hydroxy-1-(3-hydroxyphenyl)propan-2-one;(1R)-1-HYDROXY-1-(3-HYDROXYPHENYL)ACETONE;DTXSID30722602
• CAS NO: 82499-20-5
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Mol File: 82499-20-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R)-1-hydroxy-1-(3-hydroxyphenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-hydroxy-1-(3-hydroxyphenyl)propan-2-one(82499-20-5)
• EPA Substance Registry System: (1R)-1-hydroxy-1-(3-hydroxyphenyl)propan-2-one(82499-20-5)

Safety Data

• Hazardous Substances Data: 82499-20-5(Hazardous Substances Data)

Usage

General Description

(1R)-1-hydroxy-1-(3-hydroxyphenyl)propan-2-one, also known as raspberry ketone, is a natural compound found in various fruits such as raspberries, cranberries, and blackberries. It is commonly used in the food and cosmetic industries for its fruity aroma and flavor. Raspberry ketone has gained popularity as a weight loss supplement due to its potential to increase the breakdown of fat and boost metabolism. It is also being studied for its potential antioxidant and anti-inflammatory properties, as well as its potential to improve skin elasticity and reduce signs of aging. However, further research is needed to fully understand its effects on human health and its safety for long-term use.

Upstream product

• 57-60-3 piruvate 
• 100-83-4 meta-hydroxybenzaldehyde 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 54-49-9 (1R,2S)-metaraminol 

Relevant articles and documents

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

A wide range of thiamine diphosphate (ThDP)-dependent enzymes catalyze the benzoin-type carboligation of pyruvate with aldehydes. A few ThDP-dependent enzymes, such as YerE from Yersinia pseudotuberculosis (YpYerE), are known to accept ketones as acceptor substrates. Catalysis by YpYerE gives access to chiral tertiary alcohols, a group of products difficult to obtain in an enantioenriched form by other means. Hence, knowledge of the three-dimensional structure of the enzyme is crucial to identify structure–activity relationships. However, YpYerE has yet to be crystallized, despite several attempts. Herein, we show that a homologue of YpYerE, namely, PpYerE from Pseudomonas protegens (59 % amino acid identity), displays similar catalytic activity: benzaldehyde and its derivatives as well as ketones are converted into chiral 2-hydroxy ketones by using pyruvate as a donor. To enable comparison of aldehyde- and ketone-accepting enzymes and to guide site-directed mutagenesis studies, PpYerE was crystallized and its structure was determined to a resolution of 1.55 ?.