82504-15-2Relevant academic research and scientific papers
A facile method for the preparation of unsymmetrical ureas utilizing zirconium (IV) chloride
Lee, Anna,Kim, Hee-Kwon,Thompson, David H.
, p. 154 - 160 (2016/02/26)
A facile synthetic method for the preparation of unsymmetrical ureas from amines is described. Carbamoyl imidazole compounds were prepared by the reaction of 1, 1-carbonyldiimidazole with primary or secondary amines, and further activation by treatment with zirconium(IV) chloride to generate the desired urea. This reaction protocol was applied to the synthesis of tri and tetrasubstituted ureas with high yields. This study provides an alternative guideline for the practical preparation of various unsymmetrical ureas.
Hindered ureas as masked isocyanates: Facile carbamoylation of nucleophiles under neutral conditions
Hutchby, Marc,Houlden, Chris E.,Gair Ford,Tyler, Simon N. G.,Gagne, Michel R.,Lloyd-Jones, Guy C.,Booker-Milburn, Kevin I.
supporting information; experimental part, p. 8721 - 8724 (2010/01/16)
Bigger is better: Sterically hindered dialkyl ureas undergo nucleophilic substitution at dramatically faster rates than their less hindered counterparts (see scheme). Steric decompression upon the formation of an intermediate isocyanate can explain this c
