82508-07-4Relevant academic research and scientific papers
Iridium-imine and -amine complexes relevant to the (S)-metolachlor process: Structures, exchange kinetics, and C-H activation by IrI causing racemization
Dorta, Romano,Broggini, Diego,Kissner, Reinhard,Togni, Antonio
, p. 4546 - 4555 (2007/10/03)
Iridium complexes of DMA-imine [2,6-dimethylphenyl-1′-methyl- 2′-methoxyethylimine, 1a) and (R)-DMA-amine [(1′R)-2,6- dimethylphenyl-1′-methyl-2′-methoxyethylamine, 2a] that are relevant to the catalytic imine hydrogenation step of the Syngenta (S)-Metola
Preparation of (R)-2-azidoesters from 2-((p-nitrobenzene)sulfonyl)oxy esters and their use as protected amino acid equivalents for the synthesis of di- and tripeptides containing D-amino acid constituents
Hoffman,Kim
, p. 3007 - 3020 (2007/10/02)
(R)-2-Azidoesters and their derived (R)-2-azido acids are readily prepared from common amino acids by an inversion methodology that employs (S)-2-nosyloxyesters as key intermediates. The (R)-2-azidoesters can be used as protected amino acid equivalents in peptide synthesis. Basic hydrolysis frees the carboxyl group. Triphenylphosphine/water is used to free the amine group. By these reactions a variety of L-D and D-L dipeptides, L-D-L tripeptides, and depsipeptides can be prepared easily in good yields, and without detectable epimerization.
THE PREPARATION OF 2-HYDRAZINYL ESTERS IN HIGH OPTICAL PURITY FROM 2-SULFONYLOXY ESTERS
Hoffmann, Robert V.,Kim, Hwa-Ok
, p. 2953 - 2956 (2007/10/02)
Chiral 2-triflyloxy esters, prepared from chiral 2-hydroxy esters, react enantiospecifically with BocNHNH2 to produce optically pure 2-hydrazinyl ester derivatives in high yields.The reaction of 2-nosyloxy esters with BocNHNH2 gives 2-(Boc-hydrazinyl) esters, thus providing an efficient (albeit slow) method for the conversion of esters to 2-hydrazinyl ester derivatives.
