82508-08-5

Upstream product

• 69516-03-6 N-(1'-methoxy-carbonyl-ethyl)-2-methyl-6-ethyl-aniline 
• 132034-47-0 N-(2-ethyl-6-methylphenyl)-N-(1'-methoxymethyl)-ethylidene-amine 
• 24549-06-2 6-ethyl-o-toluidine 
• 82508-03-0 (S)-(-)-N-(2-Ethyl-6-methyl-phenyl)-alanin 

Downstream Products

• 87392-11-8 (aRS,1'S)-(+)-N-(1'-Methyl-2'-hydroxyethyl)-N-chloracetyl-2-ethyl-6-methylanilin 
• 87392-12-9 (S)-metolachlor 

Relevant academic research and scientific papers

FERROCENE-DIPHOSPHINE LIGANDS

Compounds of the formula (I) in the form of racemates, mixtures of stereoisomers or optically pure stereoisomers, formula (I), where X1 and X2 are each, independently of one another, a secondary phosphino group; R1 is a ha

Chemoenzymatic synthesis of the chiral herbicide: (S)-metolachlor

A chemoenzymatic approach for the production of (5)-metolachlor, one of the most widely used herbicides, has been developed. The starting material (S)-N-(2-ethyl-6-methylphenyl)alanine was obtained by the use of lipase-catalyzed hydrolytic kinetic resolution. Under the optimal conditions, the good activity and excellent enantioselectivity of lipase B from Candida antarctica (CAL-B, E > 100) are achieved in diethyl ether - water (15% v/v), which is about 9.7-fold more enantioselective than that in a pure buffered aqueous solution (E = 12.1). After a simple extraction procedure is used to separate the acid product from the remaining ester, the remaining ester is racemized, providing the basis for the continuous resolution process. Then (S)-metolachlor is synthesized by a simple chemical method using the enantiomerically pure (S)-acid.

Optically active N-(1'-methyl-2'-methoxyethyl)-N-chloroacetyl-2-ethyl-6-methylaniline as herbicide

The optically active mixture of isomers of aRS,1'S(-)-N-(1'-methyl-2'-methoxyethyl)-N-chloroacetyl-2-ethyl-6-methylaniline has improved action against problem weeds over the racemic mixture of isomers known as "Metolachlor".