82510-98-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(TRIFLUOROMETHYL)BENZAL CHLORIDE is used as a synthetic precursor for the development of various pharmaceuticals, leveraging its reactivity and the unique properties of the trifluoromethyl group to create novel drug molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(TRIFLUOROMETHYL)BENZAL CHLORIDE is utilized as a starting material for the synthesis of compounds with potential pesticidal and herbicidal properties, contributing to the development of effective crop protection agents.
Used in Dye Industry:
4-(TRIFLUOROMETHYL)BENZAL CHLORIDE is employed as a chemical intermediate in the production of dyes, where its structural features can be manipulated to achieve a range of colorants for various applications.
Used in Organic Synthesis:
4-(TRIFLUOROMETHYL)BENZAL CHLORIDE is used as a versatile building block in organic synthesis, taking advantage of the trifluoromethyl group's reactivity and the benzal chloride moiety's potential for substitution to form a wide array of functionalized compounds.
Used in Medicinal Chemistry Research:
4-(TRIFLUOROMETHYL)BENZAL CHLORIDE is utilized in medicinal chemistry research as a structural component in the design and synthesis of new molecules with potential therapeutic applications, including antimicrobial and antifungal agents, due to its inherent properties and synthetic versatility.

Upstream product

• 106-42-3 para-xylene 
• 7456-32-8 1-dichloromethyl-4-trichloromethylbenzene 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 189096-91-1 {[4-(trifluoromethyl)phenyl]methylidene}hydrazine 
• 13947-96-1 1-trichloromethyl-4-(trifluoromethyl)-benzene 

Downstream Products

• 96395-05-0 anti-9-<1-(p-trifluoromethyl)phenyl>-cis-bicyclo<6.1.0>nona-2,4,6-triene 
• 13947-96-1 1-trichloromethyl-4-(trifluoromethyl)-benzene 
• 1489331-57-8 C₁₈H₂₅F₃N₂O₂Te₂ 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Relevant academic research and scientific papers

Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides

Herein, a novel method for the transformation of aldehydes into geminal dichlorides based on phthaloyl chloride as reagent and N -formylpyrrolidine as Lewis base catalyst is disclosed. Given the mild reaction conditions, the current protocol is distinguished by high levels of functional group compatibility and scalability and is operationally simple. The in situ formation of a Vilsmeier Haack reagent type intermediate is likely to be essential for this organocatalytic nucleophilic substitution reaction.

AN IMPROVED PROCESS FOR PREPARATION OF TRIFLUOROMETHYLBENZALDEHYDES AND INTERMEDIATES THEREOF

The present invention provides an in-situ process for preparation of a compound of formula 1 and intermediate thereof, These compounds are useful chemical intermediates for the production of pesticides and pharmaceutical products.

Synthesis of Aryldihalomethanes by Denitrogenative Dihalogenation of Benzaldehyde Hydrazones

We report a denitrogenative dihalogenation reaction of phenyldiazomethanes in which the hypervalent iodine reagents PhICl2 and TolIF2 act as surrogates for elemental chlorine and fluorine. Halogen transfer from iodane to aryldiazomethane is described, as is a tandem oxidative dihalogenation reaction between iodane and hydrazone. This is the first use of non-α-stabilized diazo compounds in this reaction, which provided an efficient synthesis of aryldifluoromethane (ArCHF2) and aryldichloromethane (ArCHCl2) derivatives. (Figure presented.).

Phosphorus(V)-catalyzed deoxydichlorination reactions of aldehydes

A phosphine oxide-catalyzed conversion of aldehydes into 1,1-dichlorides is reported. The reaction proceeds via a phosphorus(V)-catalysis manifold in which phosphine oxide turnover is achieved using oxalyl chloride as a consumable reagent. The new method is applicable to a range of aldehydes and, in combination with palladium-catalyzed reductive dimerization, gives rise to a new catalytic approach to the synthesis of stilbenes and a short formal synthesis of resveratrol.

REDUKTION VON BENZOTRICHLORIDEN ZU BENZALCHLORIDEN

Benzal chlorides are prepared from the corresponding benzotrichlorides by reduction with thiophenol in the presence of catalytic amounts of copper(I) bromide.

Novel trifluoromethyl benzal chlorides and process for the preparation thereof

Novel meta- and para-trifluoromethyl benzal chlorides and ring-halogenated derivatives are useful chemical intermediates for the preparation of meta- and para-trifluoromethyl benzaldehydes and various other useful end products. The novel compounds can be