82546-91-6

Basic information

• Product Name: 2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 2-AMINO-4-ETHYL-5-METHYL-3-THIOPHENECARBOXYLATE;CHEMBRDG-BB 4143059;2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER;AKOS MSC-0424;Ethyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate;ethyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate(SALTDATA: FREE)
• CAS NO: 82546-91-6
• Molecular Formula: C₁₀H₁₅NO₂S
• Molecular Weight: 213.3
• Mol File: 82546-91-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 339.5°C at 760 mmHg
• Flash Point: 159.1°C
• Appearance: /
• Density: 1.154g/cm³
• Vapor Pressure: 9.13E-05mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(82546-91-6)
• EPA Substance Registry System: 2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(82546-91-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 82546-91-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C10H15NO2S/c1-4-7-6(3)14-9(11)8(7)10(12)13-5-2/h4-5,11H2,1-3H3

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 96-22-0 pentan-3-one 
• 107-87-9 2-Pentanone 

Downstream Products

• 549475-39-0 C₁₉H₂₃NO₃S 
• 439692-90-7 4-chloro-5-ethyl-6-methylthiopheno[2,3-d]pyrimidine 
• 1321891-12-6 5-ethyl-6-methyl-2-[(4-ethylpiperazin-1-yl)methyl]-4-phenylthiothieno[2,3-d]pyrimidine 
• 1321891-13-7 5-ethyl-6-methyl-2-[(4-ethylpiperazin-1-yl)methyl]-4-(4-methoxyphenylthio)thieno[2,3-d]pyrimidine 
• 1321891-19-3 5-ethyl-6-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-(4-methoxyphenylthio)thieno[2,3-d]pyrimidine 
• 1321891-23-9 5-ethyl-6-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-phenylthiothieno[2,3-d]pyrimidine 
• 439692-89-4 5-ethyl-6-methylthieno[2,3-d]pyrimidin-4(3H)-one 
• 82546-83-6 2-(2-Amino-4-fluoro-phenylamino)-4-ethyl-5-methyl-thiophene-3-carboxylic acid ethyl ester 
• 793716-04-8 5-ethyl-2-mercapto-3-(4-methoxy-phenyl)-6-methyl-3H-thieno[2,3-d]pyrimidin-4-one 
• 934393-81-4 4-ethyl-2-[3-(4-methoxy-phenyl)-thioureido]-5-methyl-thiophene-3-carboxylic acid ethyl ester 
• 82546-88-1 4-Ethyl-2-(4-fluoro-2-nitro-phenylamino)-5-methyl-thiophene-3-carboxylic acid ethyl ester 

Relevant articles and documents

Convenient and efficient synthesis of some novel fused thieno pyrimidines using gewald's reaction

Several functionalized thienopyrimidines were synthesized by a facile synthetic method, which includes Gewald's reaction, and were characterized by spectral and analytical data. These functionalized thienopyrimidines were converted to various new chemical

Discovery of novel dialkyl substituted thiophene inhibitors of HCV by in silico screening of the NS5B RdRp

A novel 5,4-dialkyl substituted thiophene was discovered by in silico screening of the 3D polymerase crystal structure (1GX6) that demonstrated single digit micromolar HCV inhibition activity in the replicon assay and dose-dependent inhibition in the replicase complex assay. Subsequently, SAR was explored with a small set of dialkyl and tetrahydro-benzo thiophenes. Since these thiophenes inhibit synthesis of both, single- and double-stranded RNAs, their mechanism of action is distinct from other known HCV inhibitors.

Synthesis of 2-aminothiophenes on ionic liquid phase support using the Gewald reaction

The first report of the use of task-specific ionic liquid as soluble support for the Gewald synthesis of 2-aminothiophenes is reported in this article. This synthetic method is simple and efficient, and the products are obtained in good to excellent yields with high purities, without the need for chromatographic purification. Copyright Taylor & Francis Group, LLC.