82546-91-6

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C10H15NO2S/c1-4-7-6(3)14-9(11)8(7)10(12)13-5-2/h4-5,11H2,1-3H3

Upstream product

• 107-87-9 2-Pentanone 
• 105-56-6 ethyl 2-cyanoacetate 
• 96-22-0 pentan-3-one 

Downstream Products

• 82546-88-1 4-Ethyl-2-(4-fluoro-2-nitro-phenylamino)-5-methyl-thiophene-3-carboxylic acid ethyl ester 
• 549475-39-0 C₁₉H₂₃NO₃S 
• 82546-83-6 2-(2-Amino-4-fluoro-phenylamino)-4-ethyl-5-methyl-thiophene-3-carboxylic acid ethyl ester 
• 439692-90-7 4-chloro-5-ethyl-6-methylthiopheno[2,3-d]pyrimidine 
• 1321891-12-6 5-ethyl-6-methyl-2-[(4-ethylpiperazin-1-yl)methyl]-4-phenylthiothieno[2,3-d]pyrimidine 
• 1321891-13-7 5-ethyl-6-methyl-2-[(4-ethylpiperazin-1-yl)methyl]-4-(4-methoxyphenylthio)thieno[2,3-d]pyrimidine 
• 1321891-19-3 5-ethyl-6-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-(4-methoxyphenylthio)thieno[2,3-d]pyrimidine 
• 1321891-23-9 5-ethyl-6-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-phenylthiothieno[2,3-d]pyrimidine 
• 439692-89-4 5-ethyl-6-methylthieno[2,3-d]pyrimidin-4(3H)-one 
• 793716-04-8 5-ethyl-2-mercapto-3-(4-methoxy-phenyl)-6-methyl-3H-thieno[2,3-d]pyrimidin-4-one 
• 934393-81-4 4-ethyl-2-[3-(4-methoxy-phenyl)-thioureido]-5-methyl-thiophene-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Convenient and efficient synthesis of some novel fused thieno pyrimidines using gewald's reaction

Several functionalized thienopyrimidines were synthesized by a facile synthetic method, which includes Gewald's reaction, and were characterized by spectral and analytical data. These functionalized thienopyrimidines were converted to various new chemical

Efficient synthesis of 2-substituted thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane

The carbodiimides 4, obtained from reactions of iminophosphorane 3 with aromatic isocyanates, were reacted with secondary amines to give 2-dialkylamino-5-ethyl-6-methyl-thieno[2,3-d]pyrimidin-4(3H)-ones 6 in the presence of catalytic amount of EtONa. Reac

Discovery of novel dialkyl substituted thiophene inhibitors of HCV by in silico screening of the NS5B RdRp

A novel 5,4-dialkyl substituted thiophene was discovered by in silico screening of the 3D polymerase crystal structure (1GX6) that demonstrated single digit micromolar HCV inhibition activity in the replicon assay and dose-dependent inhibition in the replicase complex assay. Subsequently, SAR was explored with a small set of dialkyl and tetrahydro-benzo thiophenes. Since these thiophenes inhibit synthesis of both, single- and double-stranded RNAs, their mechanism of action is distinct from other known HCV inhibitors.

Microwave-assisted gewald synthesis of 2-amimothio-phenes using functional ionic liquid as soluble support

A microwave-assisted liquid-phase Gewald synthesis of 2-aminothiophenes was developed using task-specific ionic liquid - [2-hydemim][BF4] as soluble support. This new synthetic method is simple and efficient, and the products are obtained in good to excellent yields with high purities, without the need for chromatographic purification.

Synthesis of 2-aminothiophenes on ionic liquid phase support using the Gewald reaction

The first report of the use of task-specific ionic liquid as soluble support for the Gewald synthesis of 2-aminothiophenes is reported in this article. This synthetic method is simple and efficient, and the products are obtained in good to excellent yields with high purities, without the need for chromatographic purification. Copyright Taylor & Francis Group, LLC.

3-(1H-tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones

3-(1H-Tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones useful as antiallergic agents are described herein. The compounds are prepared by cyclization of an appropriate substituted amidine using an alkali metal base. The reaction is carried out in an appropriate inert solvent.