82549-51-7Relevant articles and documents
Preparation method of cefteram pivoxil
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Page/Page column 9-12, (2019/11/14)
The invention relates to a preparation method of cefteram pivoxil. The preparation method comprises following steps: taking 7-ACA and 5-methyltetrazole as starting raw materials, carrying out reactions in the presence of H2SO4 to generate 7-MTCA, protecting the amino groups of aminothiazol acetate, reacting aminothiazol acetate with 7-MTCA under the catalytic effect of AlMe3 to generate an intermediate (I); carrying out esterification reactions between the intermediate (I) and iodomethyl pivalate under the action of a phase transfer catalyst and an acid adsorbent, and removing the amino protection to obtain the target product (cefteram pivoxil). The reaction conditions are mild, the product purity and yield are high, and the technology is stable, is easy for amplification, and is suitablefor industrial production.