825634-08-0Relevant articles and documents
Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity
Coelho, Alberto,Ravi?a, Enrique,Fraiz, Nuria,Yá?ez, Matilde,Laguna, Reyes,Cano, Ernesto,Sotelo, Eddy
, p. 6476 - 6484 (2008/09/17)
5-Alkylidenepyridazin-3-ones with four points of diversity (R2, R6, X, Y) have been synthesized and evaluated as platelet aggregation inhibitors. Several derivatives eliciting antiplatelet activity in the low micromolar range (e.g.,
Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions
Coelho, Alberto,Sotelo, Eddy,Novoa, Héctor,Peeters, Oswald M.,Blaton, Norbert,Ravi?a, Enrique
, p. 12177 - 12189 (2007/10/03)
In the search for novel antiplatelet agents, convenient and efficient methods for the preparation of 2,5-disubstituted pyridazin-3(2H)-ones are reported that utilise palladium-catalysed cross-coupling reactions. A post-coupling base-promoted isomerisation