825638-25-3Relevant academic research and scientific papers
Stereoselective nucleophilic fluoromethylation of aryl ketones: Dynamic kinetic resolution of chiral α-fluoro carbanions
Shen, Xiao,Miao, Wenjun,Ni, Chuanfa,Hu, Jinbo
, p. 775 - 779 (2014/01/23)
Although many methods are available for the synthesis of optically enriched monofluoromethyl secondary alcohols, synthesizing optically enriched monofluoromethyl tertiary alcohols remains a challenge. An efficient and easy-to-handle nucleophilic fluoromethylation protocol was developed. The current monofluoromethylation showed much higher facial selectivity than the corresponding difluoromethylation and proceeded via a different type of transition state. Excellent stereoselective control at the fluorinated carbon chiral center was found, an effect believed to be facilitated by the dynamic kinetic resolution of the chiral α-fluoro carbanions. Fluoromethyl fix: An efficient and easy-to-handle protocol for the stereoselective synthesis of optically pure monofluoromethyl tertiary alcohols was developed, which showed higher facial selectivity than the corresponding difluoromethylation and proceeded via a different type of transition state. Stereoselective control at the fluorinated carbon chiral center is believed to be facilitated by the dynamic kinetic resolution of the chiral α-fluoro carbanions. Copyright
Potent, selective and low-calcemic inhibitors of CYP24 Hydroxylase: 24-Sulfoximine analogues of the hormone 1α,25-dihydroxyvitamin D 3
Kahraman, Mehmet,Sinishtaj, Sandra,Dolan, Patrick M.,Kensler, Thomas W.,Peleg, Sara,Saha, Uttam,Chuang, Samuel S.,Bernstein, Galina,Korczak, Bozena,Posner, Gary H.
, p. 6854 - 6863 (2007/10/03)
A dozen 24-sulfoximine analogues of the hormone 1α,25- dihydroxyvitamin D3 were prepared, differing not only at the stereogenic sulfoximine stereocenter but also at the A-ring. Although these sulfoximines were not active transcriptionally and w
