82585-56-6

Basic information

• Product Name: (4-Methoxy-phenyl)-methyl-oxiranylmethyl-amine
• Synonyms: (4-Methoxy-phenyl)-methyl-oxiranylmethyl-amine
• CAS NO: 82585-56-6
• Molecular Weight: 193.246
• Mol File: 82585-56-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-Methoxy-phenyl)-methyl-oxiranylmethyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Methoxy-phenyl)-methyl-oxiranylmethyl-amine(82585-56-6)
• EPA Substance Registry System: (4-Methoxy-phenyl)-methyl-oxiranylmethyl-amine(82585-56-6)

Safety Data

• Hazardous Substances Data: 82585-56-6(Hazardous Substances Data)

Upstream product

• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 106-89-8 epichlorohydrin 

Downstream Products

• 82585-88-4 (6-Amino-4-{2-hydroxy-3-[(4-methoxy-phenyl)-methyl-amino]-propylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester 
• 69157-24-0 1-Amino-3-[(4-methoxy-phenyl)-methyl-amino]-propan-2-ol 

Relevant articles and documents

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.