82609-80-1

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 2133-40-6 L-proline methyl ester monohydrochloride 

Downstream Products

• 4549-02-4 maculosin-1 
• 189388-22-5 endomorphin 1 
• 130816-92-1 H-Tyr-Pro-Val-Arg-NH₂*AcOH 
• 130816-90-9 H-Tyr-Pro-Ser-Phe-NH₂*AcOH 
• 130816-91-0 H-Tyr-Pro-Phe-Val-NH₂*AcOH 
• 130816-93-2 H-Tyr-Pro-Val-Pro-NH₂*AcOH 
• 107897-28-9 Boc-Tyr-Pro-Val-Arg-NH₂ 
• 107897-27-8 Boc-Tyr-Pro-Phe-Val-NH₂ 
• 107897-26-7 Boc-Tyr-Pro-Ser-Phe-NH₂ 
• 107897-29-0 Boc-Tyr-Pro-Val-Pro-NH₂ 
• 852333-10-9 Boc-Tyr-Pro-Ser-Ser-OMe 
• 874337-72-1 H-Tyr-Pro-Ser-Ser-OMe 
• 74201-47-1 (tert-butoxycarbonyl)-L-tyrosyl-L-proline 

Relevant academic research and scientific papers

Short Synthesis of Oxetane and Azetidine 3-Aryl-3-carboxylic Acid Derivatives by Selective Furan Oxidative Cleavage

Four-membered rings remain underexplored motifs despite offering attractive physicochemical properties for medicinal chemistry. Arylacetic acids bearing oxetanes, azetidines, and cyclobutanes are prepared in two steps: a catalytic Friedel-Crafts reaction from four-membered ring alcohol substrates, followed by mild oxidative cleavage. The suitability of the products as building blocks is reflected in their facile purification and amenability to derivatization. Examples include heteroaromatics and aryltriflates, as well as oxetane-derived profen drug analogues and a new endomorphin derivative containing an azetidine amino acid residue.

AGRICULTURAL PLANT-PROTECTING AGENTS CONTAINING DIPEPTIDE DERIVATIVE AS ACTIVE INGREDIENT

Provided is an agricultural plant-protecting agent including a dipeptide derivative or an agro-pharmaceutically acceptable salt thereof as an active ingredient, which has a plant disease-preventing effect, a plant growth-promoting effect, and a plant immunity-activating effect.

COMPOUNDS FOR AMIDE-FORMING REACTIONS

Provided herein is a compound of Formula I, that displays remarkable physicochemical properties as a peptide-coupling additive for peptide-forming reactions in water, wherein said coupling reactions proceed without measurable racemization. A method of pro

A new oxyma derivative for nonracemizable amide-forming reactions in water

An Oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (2), displayed remarkable physicochemical properties as a peptide-coupling additive for peptide-forming reactions in water. Short peptides to oligopeptides could b

Efficient chemo-enzymatic synthesis of endomorphin-1 using organic solvent stable proteases to green the synthesis of the peptide

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2, EM-1), an effective analgesic, was efficiently synthesized by a combination of enzymatic and chemical methods. Peptide Boc-Trp-Phe-NH2 was synthesized with a high yield of 97.1% by the solvent-stab

An efficient green synthesis of proline-based cyclic dipeptides under water-mediated catalyst-free conditions

l-Proline-based cyclic dipeptides were synthesized from N-Boc-protected dipeptide methyl esters under catalyst-free condition using water as a solvent. One-pot deprotection and cyclization have been used as the key steps, providing an efficient and environmentally friendly approach. Clean reaction conditions, easy isolation, and good yields of cyclic dipeptides are the salient features of the proposed methodology.

Synthesis, cytotoxic and antimicrobial screening of a proline-rich cyclopolypeptide

Present study describes the first total synthesis of a cyclic heptapeptide, stylisin 1 (8) via coupling of tetrapeptide Boc-L-tyrosinyl-L-prolyl-L-leucyl- L-proline-OH and tripeptide L-phenylalanyl-L-isoleucyl-L-proline- OMe followed by cyclization of lin

Helical pores self-assembled from homochiral dendritic dipeptides based on L-Tyr and nonpolar α-amino acids

The synthesis of dendritic dipeptides (4-3,4-3,5)12G2-CH 2-Boc-L-Tyr-X-OMe where X = Gly, L-Val, L-Leu, L-lle, L-Phe, and L-Pro is reported. Their self-assembly in bulk and in solution and the structural and retrostructural analysis of their pe