82622-46-6

Basic information

• Product Name: 3-[2-(TRIFLUOROMETHYL)PHENOXY]AZETIDINE HYDROCHLORIDE
• Synonyms: 3-[2-(TRIFLUOROMETHYL)PHENOXY]AZETIDINE HYDROCHLORIDE
• CAS NO: 82622-46-6
• Molecular Formula: C₁₀H₁₀F₃NO*ClH
• Molecular Weight: 253.65
• Mol File: 82622-46-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[2-(TRIFLUOROMETHYL)PHENOXY]AZETIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(TRIFLUOROMETHYL)PHENOXY]AZETIDINE HYDROCHLORIDE(82622-46-6)
• EPA Substance Registry System: 3-[2-(TRIFLUOROMETHYL)PHENOXY]AZETIDINE HYDROCHLORIDE(82622-46-6)

Safety Data

• Hazardous Substances Data: 82622-46-6(Hazardous Substances Data)

Upstream product

• 444-30-4 2-(trifluoromethyl)phenol 
• 960492-52-8 tert-butyl 3-(2-(trifluoromethyl)phenoxy)-azetidine-1-carboxylate 

Relevant articles and documents

Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors

Potent and orally bioavailable SCD inhibitors built on an azetidinyl pyridazine scaffold were identified. In a one-month gDIO mouse model of obesity, we demonstrated that there was no therapeutic index even at low doses; efficacy in preventing weight gain

AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I)