82625-45-4Relevant articles and documents
Fluorescent probe for selectively detecting H2S based on BODIPY dye targeted lysosome as well as preparation and application of fluorescent probe
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Paragraph 0016-0018, (2021/05/05)
The invention provides a fluorescent probe for selectively responding to H2S based on BODIPY fluorescent dye targeting lysosome, and preparation and application of the probe. The probe selects BODIPY dye as a fluorophore and 2, 4-dinitrobenzenesulfonyl as a recognition group. A sensing mechanism is based on H2S to induce cracking of 2, 4-dinitrobenzenesulfonyl in the probe, so that a photoinduced electron transfer (PET) process is inhibited. The probe detects H2S through ultraviolet and fluorescence spectrometers and is not interfered by other amino acids, active sulfides, representative anions and the like, the detection process is simple, convenient, rapid and sensitive, and the detection limit is 4.75 nM. More importantly, the probe can target lysosome and detect H2S in cells at the same time, and has a good application prospect in the field of biological monitoring.
Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening
Carr, Miriam,Egan, Billy,Knox, Andrew J. S.,Lloyd, David G.,McCabe, Thomas,Meegan, Mary J.,Nevin, Daniel K.,O'Boyle, Niamh,Twamley, Brendan,Wang, Shu,Zisterer, Daniela M.
, (2020/01/31)
4-Aryl-4H-Chromene derivatives have been previously shown to exhibit anti-proliferative, apoptotic and anti-angiogenic activity in a variety of tumor models in vitro and in vivo generally via activation of caspases through inhibition of tubulin polymerisation. We have previously identified by Virtual Screening (VS) a 4-aryl-4H-chromene scaffold, of which two examples were shown to bind Estrogen Receptor α and β with low nanomolar affinity and 20-fold selectivity for α over β and low micromolar anti-proliferative activity in the MCF-7 cell line. Thus, using the 4-aryl-4H-chromene scaffold as a starting point, a series of compounds with a range of basic arylethers at C-4 and modifications at the C3-ester substituent of the benzopyran ring were synthesised, producing some potent ER antagonists in the MCF-7 cell line which were highly selective for ERα (compound 35; 350-fold selectivity) or ERβ (compound 42; 170-fold selectivity).
Ultrasound-assisted and efficient knoevenagel condensation reaction catalyzed by silica sodium carbonate nanoparticles
Pourshojaei, Yaghoub,Nikzad, Maryam,Eskandari, Khalil,Darijani, Mohammad-Hossein,Hassanzadeh, Abdolreza,Faghih-Mirzaei, Ehsan,Asadipour, Ali
, p. 19 - 28 (2018/05/26)
An efficient and ultrasound-assisted route to the synthesis of arylidene malononitriles/methylciano- or ethylciano acetates in a one-pot reaction catalyzed by silica sodium carbonate nanoparticles (SSC NPs) is described. In this reaction, SSC NPs demonstrated high efficiency as catalyst to obtain target products. By this achievement, a wide range of α,β-unsaturated compounds as Knoevenagel condensation products with good to excellent yields are obtained from reaction between numerous arylaldehydes, and malononitrile, methyl cianoacetate or ethyl cianoacetate. Target products which prepared in high yield and high purity can be candidate as important biologically active molecules. This method is an easy, cheap, rapid and highly efficient for the synthesis of desired products. In addition, capability of catalyst to separate from reaction mixture and reuse in further runs and being compatible with green chemistry are considered as other advantages of this procedure. All products were deduced from their FT-IR and FT-NMR spectroscopic and elemental analysis data.
