82632-35-7Relevant academic research and scientific papers
AN IMPROVED SYNTHESIS OF CYCLAZINES FROM 3H-PYRROLIZINES
Batroff, Volker,Flitsch, Wilhelm,Luebisch, Wilfried
, p. 1947 - 1950 (1982)
Cyclazines are obtained in moderate yields by reaction of 3H-pyrrolizines bearing conjugative substituents (Ph or CO2Me) with vinamidinium salts in the presence of strong bases.Sytheses of the previously unknown 2-phenyl-3H-pyrrolizine and 1-methox
An Improved Synthesis of Cyclazines from 3H-Pyrrolizines
Batroff, Volker,Flitsch, Wilhelm,Leaver, Derek,Skinner, David
, p. 1649 - 1658 (2007/10/02)
The reaction of 3H-pyrrolizines 3 with vinamidinium salts 4 provides a new and generally applicable route to cyclazines 5.Pyrrolizinefulvenes are intermediates of this reaction as shown using 3f as an example. - Cyclopentacyclazines 11 were prepared from the hitherto unknown 3H-pyrrolizines 3b, c, d and the pyrrolizine esters 3e, f with the cyclopentadiene iminium salt 10 under conditions which have been described previously.Additional evidence for a close similarity between cyclazines 11 and the corresponding azulenes has been obtained from the UV spectra of 11.
