82647-26-5Relevant academic research and scientific papers
Mannich products of kojic acid and N-heterocycles and their Ru(II)-arene complexes: Synthesis, characterization and stability
Kasser, Johanna H.,Kandioller, Wolfgang,Hartinger, Christian G.,Nazarov, Alexey A.,Arion, Vladimir B.,Dyson, Paul J.,Keppler, Bernhard K.
experimental part, p. 875 - 881 (2010/06/16)
Ru(II)-η6-p-cymene compounds bearing pyrone-derived ligands, which were obtained by Mannich reaction with piperidine and related analogues, have been synthesized. The compounds were characterized by NMR spectroscopy, mass spectrometry, thermogr
Basic 3-hydroxypyridin-4-ones: Potential antimalarial agents
Dehkordi, Lotfollah S.,Liu, Zu D.,Hider, Robert C.
, p. 1035 - 1047 (2008/09/20)
3-Hydroxypyridin-4-ones selectively bind iron under biological conditions and one such compound has found application in the treatment of thalassaemia-linked iron overload. Related molecules have also been demonstrated to possess an antimalarial effect at levels which are non-toxic to mammalian cells. In an attempt to improve the efficiency of such molecules we have investigated the effect of introducing basic nitrogen centres into 3-hydroxypyridin-4-ones in an attempt to achieve targeting to lysosomes and other intracellular acidic vacuoles. Several of the compounds reported in this communication possess enhanced antimalarial activity over that of the simple hydroxypyridinone class.
