82648-64-4

Upstream product

• 41613-59-6 1-ethynyl-2,2,6-trimethyl-1-cyclohexanol 
• 432-25-7 2,6,6-trimethylcyclohex-1-enecarbaldehyde 
• 100846-59-1 (2Z,4E)-3-Trifluoromethyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienoic acid methyl ester 
• 100846-51-3 (2Z,4E)-5-(1-Hydroxy-2,2,6-trimethyl-cyclohexyl)-3-trifluoromethyl-penta-2,4-dienal 
• 100846-51-3 (2E,4E)-5-(1-Hydroxy-2,2,6-trimethyl-cyclohexyl)-3-trifluoromethyl-penta-2,4-dienal 
• 100846-58-0 (E)-1,1,1-Trifluoro-4-(2,6,6-trimethyl-cyclohex-1-enyl)-but-3-en-2-one 
• 100846-48-8 1-[(E)-5-(tert-Butyl-dimethyl-silanyloxy)-3-trifluoromethyl-pent-3-en-1-ynyl]-2,2,6-trimethyl-cyclohexanol 
• 100846-46-6 (E)-5-(1-Hydroxy-2,2,6-trimethyl-cyclohexyl)-3-trifluoromethyl-pent-2-en-4-ynoic acid methyl ester 
• 100846-45-5 1,1,1-Trifluoro-4-(1-hydroxy-2,2,6-trimethyl-cyclohexyl)-but-3-yn-2-one 
• 100846-55-7 1,1,1-Trifluoro-4-(2,6,6-trimethyl-cyclohex-1-enyl)-but-3-yn-2-one 
• 100846-52-4 (2E,4E,6Z,8E)-9-(1-Hydroxy-2,2,6-trimethyl-cyclohexyl)-3-methyl-7-trifluoromethyl-nona-2,4,6,8-tetraenoic acid methyl ester 
• 82690-66-2 9-cis-19,19,19-trifluororetinal 
• 4834-02-0 4-diethoxyphosphoryl-3-methyl-but-2-enoic acid methyl ester 
• 100846-62-6 (2Z,4E)-3-Trifluoromethyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienal 

Relevant academic research and scientific papers

9-CIS AND 11-CIS ISOMERS OF 18,18,18-, 19,19,19- AND 20,20,20-TRIFLUORORETINAL

The preparation and properties of the 9-cis and 11-cis isomers of three trifluoromethylated retinals are described.

PREPARATION OF 19,19,19-TRIFLUORORETINAL(9-TRIFLUOROMETHYLRETINAL)

Synthetic work of all-trans-19,19,19-trifluororetinal (7E,9Z,11E,13E) is described.

Fluorinated Retinoids via Crossed Aldol Condensation of 1,1,1-Trifluoroacetone

Piperidine-acetic acid catalyzed crossed aldol condensation of 1,1,1-trifluoroacetone with aryl or α,β-unsaturated aldehydes was found to be a useful method for the preparation of unsaturated trifluoromethyl ketones.Chain extension of these ketones led to several new fluorinated retinoids including the hitherto elusive all-trans isomers of 19,19,19- and 20,20,20-trifluororetinal.