82652-59-3Relevant academic research and scientific papers
SYNTHESIS OF (-)-AMBROX FROM l-ABIETIC ACID
Koyama, Hiroo,Kaku, Yumiko,Ohno, Masaji
, p. 2863 - 2866 (1987)
Synthesis of (-)-ambrox 1 has been completed stereoselectively starting from l-abietic acid 2 .
First synthesis of antitumoral dasyscyphin B
Akhaouzan, Ali,Fernández, Antonio,Mansour, Ahmed I.,Alvarez, Esteban,Haid?ur, Ali,Alvarez-Manzaneda, Ramón,Chahboun, Rachid,Alvarez-Manzaneda, Enrique
, p. 6176 - 6185 (2013/09/12)
The first synthesis of dasyscyphin B, an antitumoral metabolite obtained from the ascomycete Dasyscyphus niveus, has been achieved starting from commercial abietic acid. The key steps of the synthetic sequence are the diastereoselective α-methylation of a ketoaldehyde, followed by an intramolecular aldol condensation and the further Diels-Alder cycloaddition of a dienol ester. The procedure reported will allow the synthesis of related metabolites functionalized in the A ring. The Royal Society of Chemistry.
