82657-72-5

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry:
1-(BROMOMETHYL)-2-PHENOXYBENZENE is used as a key intermediate in the synthesis of various pharmaceutical compounds and drug candidates. Its bromomethyl group can be used for further functionalization, allowing the creation of new molecules with potential therapeutic properties.
Used in the Preparation of CRAC Channels:
1-(BROMOMETHYL)-2-PHENOXYBENZENE is used in the preparation of CRAC (Ca2+ release-activated Ca2+) channels using photoswitchable azopyrazoles. These channels play a crucial role in cellular calcium signaling, and their modulation can have significant implications in various physiological processes and potential therapeutic applications.
Used in Materials Science:
1-(BROMOMETHYL)-2-PHENOXYBENZENE can be employed in the development of new materials with specific properties, such as photoresponsive materials or materials with tailored chemical reactivity. Its ability to undergo various chemical reactions makes it a versatile building block for the design of advanced materials.

InChI:InChI=1/C13H11BrO/c14-10-11-6-4-5-9-13(11)15-12-7-2-1-3-8-12/h1-9H,10H2

Upstream product

• 3991-61-5 1-methyl-2-phenoxybenzene 
• 13807-84-6 (2-phenoxyphenyl)methanol 
• 19434-34-5 2-(phenoxy)benzaldehyde 
• 2243-42-7 2-phenoxybenzoic acid 
• 21905-56-6 methyl 2-phenoxybenzoate 

Downstream Products

• 107624-14-6 (2-phenoxyphenyl)methanamine 
• 19434-34-5 2-(phenoxy)benzaldehyde 
• 948850-53-1 2-phenoxybenzylzinc bromide 
• 1093231-93-6 diethyl 2-(4-chlorophenoxy)-2-(2-phenoxybenzyl)malonate 
• 1253113-40-4 ethyl 1-{[2-(phenyloxy)phenyl]methyl}-1H-pyrazole-3-carboxylate 
• 1253188-41-8 2-(1-{[2-(phenyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione 
• 1373394-69-4 2,6-difluoro-N-(1-{[2-(phenyloxy)phenyl]methyl}-1H-pyrazol-4-yl)benzamide 
• 329980-56-5 Br^(1-)*C₃₁H₂₆OP⁽¹⁺⁾ 
• 28994-41-4 o-Benzylphenol 
• 3991-61-5 1-methyl-2-phenoxybenzene 
• 1384129-37-6 C₂₁H₂₃NO₅ 
• 1181079-95-7 3-(2-chloro-6-trifluoromethylpyridin-3-yl)-5,5-dimethyl-1-(2-phenoxybenzyl)imidazolidine-2,4-dione 
• 1181078-92-1 4-[4,4-Dimethyl-2,5-dioxo-3-(2-phenoxybenzyl)-imidazolidin-1-yl]-benzonitrile 
• 1179906-97-8 tert-butyl 2-methyl-2-(2-phenoxybenzylamino)propionate 

Relevant academic research and scientific papers

Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles

The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated physiological processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca2+ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.

Benzylic C?H Functionalisation by [Et3SiH+KOtBu] leads to Radical Rearrangements in o-tolyl Aryl Ethers, Amines and Sulfides

Reaction of Et3SiH+KOtBu with diaryl ethers, sulfides and amines that feature an ortho alkyl group leads to rearrangement products. The rearrangements arise from formation of benzyl radicals, likely formed through hydrogen atom abstraction by triethylsilyl radicals. The rearrangements involve cyclisation of the benzyl radical onto the partner arene, which, from computation, is the rate determining step. In the case of diaryl ethers, Truce-Smiles rearrangements arise from radical cyclisations to form 5-membered rings, but for diarylamines, cyclisations to form dihydroacridines are observed. (Figure presented.).

AMINOPEPTIDASE A INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.

One-Step Synthesis of Substituted Benzofurans from ortho- Alkenylphenols via Palladium-Catalyzed C=H Functionalization

A dehydrogenative oxygenation of C(sp2)=H bonds with intramolecular phenolic hydroxy groups has been developed, which provides a straightforward and concise access to structurally diversely benzofurans from ortho-alkenylphenols. The reaction is catalyzed by palladium on carbon (Pd/C) without any oxidants and sacrificing hydrogen acceptors.

Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof

The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof

The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.

Novel highly potent and selective nonsteroidal aromatase inhibitors: Synthesis, biological evaluation and structure-activity relationships investigation

In further pursuing our search for potent and selective aromatase inhibitors, a new series of molecules was designed and synthesized, exploring possible structural modifications of a previously identified xanthone scaffold. Among them, highly potent compounds, with inhibitory activity in the low nanomolar range, were found. In particular, substitution of the heterocyclic oxygen atom in the xanthone core by a sulfur atom and/or increase in structure flexibility seemed to be favorable for the interaction with the enzyme.

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

Imidazo heterocyclic compounds

A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.