82671-06-5

Basic information

• Product Name: 2,6-Dichloro-5-fluoronicotinic acid
• Synonyms: 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid,97%;2,6-Dichloro-5-fluoronicotic acid;3-Pyridinecarboxylic acid, 2,6-dichloro-5-fluoro-;2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, 97% 5GR;2,6-Dichloro-5-Fluoronicotinic API;2,6-Dichloro-5-fouoro-3-pyridinecarboxylicacid;2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, 3-Carboxy-2,6-dichloro-5-fluoropyridine;Fluorine chlorine niacin
• CAS NO: 82671-06-5
• Molecular Formula: C₆H₂Cl₂FNO₂
• Molecular Weight: 209.99
• EINECS: 1592732-453-0
• Product Categories: Pyridines;Chloropyridines;Fluoropyridines;Halopyridines;Carboxylic Acids;Fluorine series;carboxylic acid| alkyl chloride| alkyl Fluorine;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Carboxylic Acids
• Mol File: 82671-06-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 152-155 °C(lit.)
• Boiling Point: 247°C (rough estimate)
• Flash Point: 156.6 °C
• Appearance: light yellow to beige fine crystalline powder
• Density: 1.6207 (estimate)
• Vapor Pressure: 0.029mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.38±0.32(Predicted)
• BRN: 4311035
• CAS DataBase Reference: 2,6-Dichloro-5-fluoronicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-5-fluoronicotinic acid(82671-06-5)
• EPA Substance Registry System: 2,6-Dichloro-5-fluoronicotinic acid(82671-06-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 1
• HazardClass: IRRITANT
• Hazardous Substances Data: 82671-06-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 82671-06-5 differently. You can refer to the following data:
1. 2,6-Dichloro-5-fluoronicotinic Acid is a useful reagent for the modulation of protein-?protein interactions to learn about the mechanisms in amyloid assembly.
2. 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid (2,6-Dichloro-5-fluoro-3-pyridinecarboxylic acid) may be used in the preparation of self assembled monolayer (SAMs) compounds.

General Description

2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a halogenated heterocyclic compound. Its density has been reported to be 1.6207g/cm3 at 25°C.

InChI:InChI=1/C8H6BrFO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,1H3

Upstream product

• 82671-03-2 ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate 
• 100-70-9 2-Cyanopyridine 
• 82671-02-1 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile 
• 104866-50-4 2,6-dichloro-5-fluoro-3-trichloromethyl-pyridine 
• 148874-68-4 methyl 2,6-dihydroxy-5-fluoronicotinate 
• 113237-20-0 2,6-dichloro-5-fluoropyridine-3-carboxamide 

Downstream Products

• 96568-02-4 2,6-dichloro-5-fluoro-3-nicotinoyl chloride 
• 402-66-4 5-fluoropyridine-3-carboxylic acid 
• 82671-03-2 ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate 
• 832088-28-5 2-chloro-6-[4-(ethoxycarbonyl)piperidin-1-yl]-5-fluoronicotinic acid 
• 943025-86-3 2-chloro-5-fluoro-6-methoxynicotinic acid 
• 1168091-26-6 6-chloro-5-fluoro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinic acid 
• 1352624-90-8 5-Chloro-6-fluoro-3-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-b] pyridin-2-one 
• 1424328-59-5 C₇HCl₂FN₂O₂S 
• 1424328-70-0 C₇HCl₂FN₂OS₂ 
• 113237-20-0 2,6-dichloro-5-fluoropyridine-3-carboxamide 
• 1429481-18-4 C₆H₃Cl₂FN₂S 
• 1373863-09-2 5-fluoro-6-(2,2,2-trifluoroethoxy)nicotinic acid 
• 132195-60-9 7-((S)-3-Amino-pyrrolidin-1-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 138668-53-8 1-(2,4-Difluoro-phenyl)-6-fluoro-5-methyl-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 

Relevant articles and documents

ANTIVIRAL AND ANTIMICROBIAL COMPOUNDS

Disclosed are guanidine and biguanidine derivatives which have anti-viral and antibacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active ingredient, and anti-viral and anti-bacterial methods utilizing such compounds. Methods of treating infections using the guanidine and biguanidine derivatives are also disclosed.

Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride

An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.

Fluorinated pyrido[2,3-c]pyridazines. I. Reductive cyclization of ethyl 2-diazo-2-(5-fluoro-2-hal-onicotinoyl)acetate with trialkylphosphine

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