82671-54-3Relevant academic research and scientific papers
Reaction of pyrylium salts with nucleophiles. Part 25. Formation of pyridine-1-oxides, 2-isoxazolines and 1-pyrazoline-1-oxides
Uncuta, Cornelia,Caproiu, Miron Teodor,Campeanu, Valentin,Petride, Aurica,Danila, Mariana G.,Plaveti, Marieta,Balaban, Alexandru T.
, p. 9747 - 9764 (2007/10/03)
The reaction of tri- and tetrasubstituted pyrylium salts with hydroxylamine affords acyclic keto-ketoximes (to be described in a separate paper) which cyclize yielding pyridine-1-oxides and/or 2-isoxazolines. Both these classes of compounds, with many possible applications, can thus be obtained simply and in good yield. The regioselectivity of 2-isoxazoline formation from unsymetrically substituted pyrylium salts is discussed. An unprecedented minor product formed from 2,6-di-t-butyl-4-methylpyrylium perchlorate and two molecules of hydroxylamine is the corresponding 1- pyrazoline-1-oxide. Mechanistic rationalization of all products are provided.
NITRATION OF ALKYL-SUBSTITUTED 4-ARYL(BENZOYL)PYRIDINES
Prostakov, N. S.,Soldatenkov, A. T.,Krapivko, A. P.,Fomichev, A. A.,Mikaya, A. I.,Ustenko, A. A.
, p. 958 - 963 (2007/10/02)
The nitration of 4-aryl- and 4-benzoylpyridines substituted with alkyl groups in the pyridine ring was realized.The isomeric nitro products were identified by analysis of the PMR spectra and by chromato-mass spectrometry.The dependence of the ratio of the obtained isomers on the strucutre of the initial compounds was established.
