82677-85-8Relevant academic research and scientific papers
Palladium-catalyzed Sonogashira coupling of amides: Access to ynones: Via C-N bond cleavage
Cui, Ming,Wu, Hongxiang,Jian, Junsheng,Wang, Hui,Liu, Chao,Daniel, Stelck,Zeng, Zhuo
, p. 12076 - 12079 (2016/10/13)
The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C-N bond. Notably, the new approach employs N-acylsaccharins as coupling partners to give ynones in good to excellent yield. This protocol can be efficiently utilized in the synthesis of a broad array of ynones under low catalyst loading and Cu-free conditions.
A general palladium-catalyzed carbonylative sonogashira coupling of aryl triflates
Wu, Xiao-Feng,Sundararaju, Basker,Neumann, Helfried,Dixneuf, Pierre H.,Beller, Matthias
supporting information; experimental part, p. 106 - 110 (2011/03/19)
Trifling with triflates: A new protocol for the carbonylative Sonogashira reactions of aryl triflates (see scheme) that provides a significant extension of this interesting methodology is described.
