827-20-3 Usage
General Description
5-Fluoro-2-(trifluoromethyl)aniline is a chemical compound described by its formula C8H5F4N. 5-FLUORO-2-(TRIFLUOROMETHYL)ANILINE largely falls under the category of organofluorines, which are organic compounds that contain fluorine. The presence of fluorine in this chemical composition indicates that it might be used in the pharmaceutical industry due to fluorine's role in improving the bioactivity of drugs. Also, the "aniline" portion suggests that it may be used in manufacturing dyes, drugs, and plastics. The compound's physical properties or specific uses, its toxicity, bioactivity, environmental impact, or health effects are not routinely mentioned in its fundamental description, and they would normally require further research.
Check Digit Verification of cas no
The CAS Registry Mumber 827-20-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 827-20:
(5*8)+(4*2)+(3*7)+(2*2)+(1*0)=73
73 % 10 = 3
So 827-20-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H5F4N/c8-4-1-2-5(6(12)3-4)7(9,10)11/h1-3H,12H2
827-20-3Relevant articles and documents
Coordinating Activation Strategy-Induced Selective C?H Trifluoromethylation of Anilines
Xu, Jun,Cheng, Ke,Shen, Chao,Bai, Renren,Xie, Yuanyuan,Zhang, Pengfei
, p. 965 - 970 (2018/02/12)
A simple protocol for the synthesis of 2-(trifluoromethyl)aniline derivatives through a coordinating activation strategy was developed. The reaction showed good reactivity and gave the target products in moderate to good yields. Pleasingly, the directing group could be recovered in excellent yield. Furthermore, this strategy allowed efficient access to the synthesis of floctafenine. A single-electron-transfer mechanism was proposed to be responsible for this trifluoromethylation reaction.
