827022-97-9Relevant articles and documents
Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists
Zhao, Hongyu,Xin, Zhili,Patel, Jyoti R.,Nelson, Lissa T. J.,Liu, Bo,Szczepankiewicz, Bruce G.,Schaefer, Verlyn G.,Falls, H. Douglas,Kaszubska, Wiweka,Collins, Christine A.,Sham, Hing L.,Liu, Gang
, p. 1825 - 1828 (2007/10/03)
The structure-activity relationship studies on a series of tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists are discussed. It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective
TETRALINE DERIVATIVES AS GHRELIN RECEPTOR MODULATORS
-
Page 19, (2010/02/10)
The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation
Zhao, Hongyu,Xin, Zhili,Liu, Gang,Schaefer, Verlyn G.,Falls, H. Douglas,Kaszubska, Wiweka,Collins, Christine A.,Sham, Hing L.
, p. 6655 - 6657 (2007/10/03)
A case study of rational design of an efficient, specific, and proprietary molecular scaffold based on the structure-activity relationship (SAR) information on a screening hit is described. Potent, selective, and orally bioavailable tetralin carboxamide g