827034-75-3

Upstream product

• 785-56-8 3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride 
• 100-46-9 benzylamine 
• 725-89-3 3,5-bistrifluoromethylbenzoic acid 
• 401-96-7 3,5-bis(trifluoromethyl)benzoyl fluoride 

Downstream Products

• 1384953-86-9 C₂₀H₂₃F₆NSi 
• 511256-30-7 N-benzyl-1-(3,5-bis(trifluoromethyl)phenyl)methanamine 

Relevant academic research and scientific papers

Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E

The synthesis of acyl fluorides using the deoxofluorination reaction of carboxylic acids using XtalFluor-E is described. This transformation, assisted by a catalytic amount of NaF, occurs at room temperature in EtOAc, where XtalFluor-E behaves as the activating agent and the fluoride source. A wide range of acyl fluorides were obtained in moderate to excellent yields (36-99%) after a simple filtration on a pad of silica gel. We also demonstrated that sequential deoxofluorination/amidation was possible.

Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained β-amino acid derivatives

A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane carboxylic acid derivatives.