827045-27-2

Upstream product

• 108-24-7 acetic anhydride 
• 827045-22-7 (3aS,5R,6S,7aR)-5,6-Diphenyl-hexahydro-[1,4]dioxino[2,3-d]imidazol-2-one 
• 579-43-1 (1S,2R)-1,2-diphenylethane-1,2-diol 

Relevant academic research and scientific papers

Catalytic dissymmetrization of meso-2-imidazolidinones: Alternative route to chiral synthons for 1,2-diamines

The chiral functionalization of a simple heterocycle, 1,3-dihydro-2- imidazolone, was achieved by the highly enantioselective monodeacylation of meso-1,3-diacetyl-2-imidazolidinones via an oxazaborolidine-catalyzed borane reduction. This kinetically controlled dissymmetrization is sufficiently effective to provide a synthetic route to either enantiomer of (4S, 5S)- or (4R, 5R)-4,5-dimethoxy-2-imidazolidinone derivatives, which serve as chiral synthons for threo-1,2-diamines.