82711-97-5

Usage

Uses

Used in Organic Synthesis:
5-fluoro-2-nitrobenzene-1-sulfonyl chloride is used as a reactive intermediate and building block for the synthesis of various organic compounds. Its unique structure allows for versatile reactivity, making it a valuable tool in creating new chemical entities.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 5-fluoro-2-nitrobenzene-1-sulfonyl chloride is utilized as a key component in the development of new drugs. Its ability to modify nucleophilic molecules makes it instrumental in the synthesis of sulfonamide derivatives and other biologically active compounds, contributing to the advancement of drug discovery and therapeutic applications.
Used in Agrochemicals:
5-fluoro-2-nitrobenzene-1-sulfonyl chloride also finds application in the agrochemical sector, where it serves as a building block for the synthesis of various agrochemicals. Its reactivity and potential to create new chemical entities with desired properties make it a valuable asset in the development of effective and environmentally friendly agricultural products.

Upstream product

• 351-28-0 N-(3-fluorophenyl)acetamide 
• 701-27-9 3-fluorobenzene-1-sulfonyl chloride 
• 2369-11-1 5-fluoro-2-nitroaniline 

Downstream Products

• 1290634-29-5 5-fluoro-N-methyl-2-nitrobenzenesulfonamide 
• 1290634-30-8 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methyl-2-nitrobenzenesulfonamide 
• 1290634-33-1 2-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methylbenzenesulfonamide 
• 1247431-23-7 5-fluoro-2-nitrobenzenesulfonamide 
• 1394084-62-8 2-amino-5-fluoro-N-quinolin-8-yl-benzenesulfonamide 

Relevant academic research and scientific papers

Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors

Structural optimization of salicylamide-based hemagglutinin (HA) inhibitor 1 resulted in the identification of cis-3-(5-hydroxy-1,3,3- trimethylcyclohexylmethylamino)benzenesulfonamide 28 and its derivatives as potent anti-influenza agents. The lead compo

Synthesis of isomeric fluoronitrobenzene-sulfonyl chlorides

The synthesis of five hitherto unknown isomeric fluoronitrobenzenesulfonyl chlorides is described. The compounds are prepared from difluoronitrobenzenes by a two-step procedure. In the first step the starting compounds undergo a regioselective reaction with phenylmethanethiol giving rise to the corresponding thioethers. The oxidative cleavage of the latter with chlorine results in the sulfonyl chlorides in good yields. One example of a threefold sequential functionalization of 2-fluoro-6-nitrobenzenesulfonyl chloride showing the synthetic utility of the title compounds is provided.

Zur Synthese sulfonierter Derivate von 4-Fluoranilin

Syntheses of Sulfonated Derivatives of 4-Fluoroaniline; Synthesis of 2-amino-5-fluorobenzenesulfonic acid (2) was achieved by baking the hydrogen sulfate of 4-fluoroaniline (1).Sulfonation of p-fluoroacetanilide (4) with oleum followed by hydrolysis gave 5-amino-2-fluorobenzenesulfonic acid (3).The same reaction with 1 yielded 3 in an impure state.The structures of 2 and 3 were confirmed by converting the diazonium chlorides derived from 5-fluoro-2-nitroaniline (5) and from 2-fluoro-5-nitroaniline (8) to 5-fluoro-2-nitrobenzenesulfonyl chloride (6) and 2-fluoro-5-nitrobenzenesulfonyl chloride (9), respectively, followed by hydrolysis of 6 to 5-fluoro-2-nitrobenzenesulfonic acid (7), and of 9 to 2-fluoro-5-nitrobenzenesulfonic acid (10), and by final reduction.Compound 10 was also obtained by sulfonation of 1-fluoro-4-nitrobenzene (11) with oleum.