82721-94-6

Basic information

• Product Name: 2-(N-methyl-N-phenylamino)-4,5,6,7-tetrahydrobenzothiazole
• CAS NO: 82721-94-6
• Molecular Weight: 244.36
• Mol File: 82721-94-6.mol

Chemical Properties

• CAS DataBase Reference: 2-(N-methyl-N-phenylamino)-4,5,6,7-tetrahydrobenzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-methyl-N-phenylamino)-4,5,6,7-tetrahydrobenzothiazole(82721-94-6)
• EPA Substance Registry System: 2-(N-methyl-N-phenylamino)-4,5,6,7-tetrahydrobenzothiazole(82721-94-6)

Safety Data

• Hazardous Substances Data: 82721-94-6(Hazardous Substances Data)

Upstream product

• 822-87-7 2-Chlorocyclohexanone 
• 100-61-8 N-methylaniline 

Relevant articles and documents

A NEW GENERAL SYNTHESIS OF 2-(N-MONO- AND N-DI-SUBSTITUTED AMINO)THIAZOLES

Although α-mercapto ketones react with cyanamides to give substituted 2-aminothiazoles the yields are satisfactory in only the simplest cases.However, a range of 2-aminothiazoles with substituents on the ring or the exo-nitrogen atom was obtained efficiently by the following one-pot procedure: a solution of an α-mercapto ketone anion was generated by treating an O-ethyl S-2-oxoethyl dithiocarbonate with piperidine at 20 deg C, a cyanamide was added, and the solution was heated for 3-6 h.

A New General Synthesis of N-Mono- and N-Di-substituted 2-Aminothiazoles

Solutions of α-mercapto-ketone anions, generated from O-ethyl S-2-oxoethyl dithiocarbonates and piperidine, react with cyanamides to give 2-aminothiazoles with substituents on the heterocycle or the exo-nitrogen atom.