82726-77-0

Basic information

• Product Name: 2-(TRIFLUOROACETYL)CYCLOHEPTANONE
• Synonyms: 2-(TRIFLUOROACETYL)CYCLOHEPTANONE;Cycloheptanone, 2-(trifluoroacetyl)- (9CI);Cycloheptanone,2-(2,2,2-trifluoroacetyl)-;2-(2,2,2-trifluoroacetyl)cycloheptan-1-one
• CAS NO: 82726-77-0
• Molecular Formula: C₉H₁₁F₃O₂
• Molecular Weight: 208.18
• Product Categories: ACETYLHALIDE
• Mol File: 82726-77-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(TRIFLUOROACETYL)CYCLOHEPTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROACETYL)CYCLOHEPTANONE(82726-77-0)
• EPA Substance Registry System: 2-(TRIFLUOROACETYL)CYCLOHEPTANONE(82726-77-0)

Safety Data

• Hazardous Substances Data: 82726-77-0(Hazardous Substances Data)

Usage

Structure

Cyclohexanone derivative with a trifluoroacetyl group attached to the cycloheptane ring

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals, building block in organic synthesis for the preparation of various compounds

Versatility

The trifluoroacetyl group can undergo various chemical reactions

Value

A valuable tool in the development of new chemical entities due to its properties and reactivity

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 502-42-1 cycloheptanone 

Downstream Products

• 312316-75-9 [3-hydroxy-3-(trifluoromethyl)-3a,4,5,6,7,8-hexahydrocyclohepta[c]pyrazol-2(3H)-yl]phenylketone 

Relevant articles and documents

2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative and preparing method and application thereof

The invention belongs to the field of chemical pharmaceuticals, and particularly relates to a 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative and a preparing method and application thereof. The structure of the 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative is shown in the formula I. A compound of the 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative has the good HCV inhibitory effect, and meanwhile shows the low cytotoxicity, and a new method is provided for development of an anti-HCV inhibitor. The general formula is defined in the description.

Fused 3-hydroxy-3-trifluoromethylpyrazoles inhibit mutant huntingtin toxicity

Here, we describe the selection and optimization of a chemical series active in both a full-length and a fragment-based Huntington's disease (HD) assay. Twenty-four thousand small molecules were screened in a phenotypic HD assay, identifying a series of compounds bearing a 3-hydroxy-3- trifluoromethylpyrazole moiety as able to revert the toxicity induced by full-length mutant Htt by up to 50%. A chemical exploration around the series led to the identification of compound 4f, which demonstrated to be active in a Htt171-82Q rat primary striatal neuron assay and a PC12-Exon-1 based assay. This compound was selected for testing in R6/2 mice, in which it was well-tolerated and showed a positive effect on body weight and a positive trend in preventing ventricular volume enlargment. These studies provide strong rationale for further testing the potential benefits of 3-hydroxy-3-trifluoromethylpyrazoles in treating HD.