82726-79-2Relevant academic research and scientific papers
Halogenation of fluorinated cyclic 1,3-dicarbonyl compounds: new aspects of synthetic application
Sevenard, Dmitri V.,Vorobyev, Mikhail,Sosnovskikh, Vyacheslav Ya.,Wessel, Helma,Kazakova, Olesya,Vogel, Vera,Shevchenko, Nikolay E.,Nenajdenko, Valentine G.,Lork, Enno,R?schenthaler, Gerd-Volker
, p. 7538 - 7552 (2009/12/06)
In order to elaborate on an approach towards 2-(fluoroacyl)phenols being the superior alternative to the conventional Fries-rearrangement based methodology, the behaviour of cyclic fluorinated 1,3-dicarbonyls in reactions with halogenating agents was examined. The synthetic relevance of the polyhalogenated compounds obtained was demonstrated by the synthesis of several new heterocycles. An aromatization via a halogenation-dehydrohalogenation sequence proved to be a rewarding synthetic route to 2-(fluoroacyl)phenols and previously unknown 3-(fluoroacyl)thiochromones. The structure of one of the synthesized compounds was confirmed by X-ray diffraction analysis.
4-Dimethylamino-1-trifluoroacetylpyridinium trifluoroacetate: An efficient reagent for the preparation of trifluoromethyl 1,3-dicarbonyl compounds
Simchen, Gerhard,Schmidt, Andreas
, p. 117 - 120 (2007/10/03)
Enamines 2 and O-trimethylsilyl ketene acetals 4 are trifluoroacetylated on reaction with the title reagent to yield trifluoroacetyl enamines 3 and trifluoromethylsilylenol ethers 5, respectively. Trifluoromethyl 1,3-diketones 6 and trifluoromethyl β-keto esters 7 are obtained by hydrolysis of compounds 3 and 5.
