827318-96-7Relevant academic research and scientific papers
1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile
Fancelli, Daniele,Moll, Jürgen,Varasi, Mario,Bravo, Rodrigo,Artico, Roberta,Berta, Daniela,Bindi, Simona,Cameron, Alexander,Candiani, Ilaria,Cappella, Paolo,Carpinelli, Patrizia,Croci, Walter,Forte, Barbara,Giorgini, Maria Laura,Klapwijk, Jan,Marsiglio, Aurelio,Pesenti, Enrico,Rocchetti, Maurizio,Roletto, Fulvia,Severino, Dino,Soncini, Chiara,Storici, Paola,Tonani, Roberto,Zugnoni, Paola,Vianello, Paola
, p. 7247 - 7251 (2006)
The optimization of a series of 5-phenylacetyl 1,4,5,6-tetrahydropyrrolo[3, 4-c]pyrazole derivatives toward the inhibition of Aurora kinases led to the identification of compound 9d. This is a potent inhibitor of Aurora kinases that also shows low nanomol
PYRROLO[3,4-c]PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
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Page/Page column 24, (2008/06/13)
Pyrrolo[3,4-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention m
