827320-73-0Relevant academic research and scientific papers
Direct functionalization of (Un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: Two metals, two mechanisms
Ghobrial, Michael,Schnuerch, Michael,Mihovilovic, Marko D.
, p. 8781 - 8793 (2011)
A highly facile, straightforward synthesis of 1-(3-indolyl)- tetrahydroisoquinolines was developed using either simple copper or iron catalysts. N-protected and unprotected tetrahydroisoquinolines (THIQ) could be used as starting materials. Extension of t
Di-tert-butyl Peroxide (DTBP)-Mediated Oxidative Cross- Coupling of Isochroman and Indole Derivatives
Jin, Likun,Feng, Jie,Lu, Guoping,Cai, Chun
supporting information, p. 2105 - 2110 (2015/06/23)
A metal-free C-C bond formation method via the oxidative cross-coupling reaction of isochroman and indole derivatives was established. Various α-fuctionalized cyclic ethers were achieved in satisfactory yields using di-tert-butyl peroxide (DTBP) as the oxidant. This method is also a potentially efficient strategy for the construction of cyclic ether-containing targets.
Facile, solvent and ligand free iron catalyzed direct functionalization of N-protected tetrahydroisoquinolines and isochroman
Ghobrial, Michael,Harhammer, Karin,Mihovilovic, Marko D.,Schnuerch, Michael
supporting information; experimental part, p. 8836 - 8838 (2011/02/21)
An efficient method for an iron catalyzed oxidative indolation and methoxyphenylation of N-protected tetrahydroisoquinolines and isochroman is described including subsequent facile deprotection. The Royal Society of Chemistry 2010.
