827325-34-8Relevant articles and documents
Carboplatin derivatives with superior antitumor activity compared to the parent compound
Bernhardt, Günther,Brunner, Henri,Gruber, Nick,Lottner, Christian,Pushpan, Simi K.,Tsuno, Takashi,Zabel, Manfred
, p. 4452 - 4466 (2004)
New carboplatin derivatives were synthesized by introducing fluoro, chloro, bromo and hydroxy substituents into the cyclobutane ring. The carboxylic acid groups were used for complexation to the Pt(NH3)2 fragment as non-leaving group. The antiproliferative activity of the new carboplatin analogues were studied in tests with J82, SK-OV-3 and NIH:OVCAR-3 cancer cells. The best compounds were two times as active as carboplatin itself. A series of new carboplatin derivatives was synthesized by introducing fluoro, chloro, bromo and hydroxy substituents into the cyclobutane ring. The carboxylic acid groups were used for the complexation with platinum(II) fragments bearing two ammonia and (RR/SS)-trans-1,2-diaminocyclohexane ligands, respectively, as non-leaving groups. The antiproliferative activity of the new carboplatin analogues differing in the cyclobutanedicarboxylate ligands and the type of platinum fragment were studied in tests with J82 bladder cancer cells and SK-OV-3 as well as cisplatin-resistant NIH:OVCAR-3 ovarian cancer cells. The most active compounds were the 3-fluoro, 3-chloro and 3,3-difluoro derivatives of carboplatin. NMR spectroscopy showed that cis-diammine(3-chloro-1,1- cyclobutanedicarboxylato)platinum(II) was hydrolyzed much faster than carboplatin explaining its higher cytostatic activity.
