827346-30-5

Upstream product

• 6195-54-6 3',5-diacetoxy-7-[hexa-O-acetyl-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]-4'-methoxyflavone 
• 827346-24-7 3-bromo-octaacetyldiosmin 

Downstream Products

• 890661-60-6 3-bromodiosmetin 7-isopropyl ether 
• 890661-65-1 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 7,3'-dibenzyl ether 
• 890661-66-2 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 7,3'-dibenzyl-5-methyl ether 
• 890661-67-3 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 3'-benzyl-5-methyl ether 
• 890661-71-9 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 7-isopropyl ether 
• 890661-61-7 3-bromodiosmetin 7-benzyl ether 
• 890661-62-8 3-bromodiosmetin 7,3'-dibenzyl ether 

Relevant academic research and scientific papers

Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins

Twenty new hybrid compounds with both combretastatin and flavone moieties were synthesized. These derivatives are classified according to the position of the trimethoxyphenyl ring at C-2 or C-3 of the chromone and presence or absence of a carbonyl as a linker between C-3 and the aryl ring. Most of these compounds were prepared from hesperidin or naringin, two natural and abundant Citrus flavonoids. Seven of these combretastatin analogues revealed anti-tubulin activity but in a medium range.