82746-41-6Relevant academic research and scientific papers
Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents
Lucescu, Liliana,B?cu, Elena,Belei, Dalila,Dubois, Jo?lle,Ghinet, Alina
, p. 479 - 488 (2016/07/19)
A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c
Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents
Lucescu, Liliana,B?cu, Elena,Belei, Dalila,Dubois, Jo?lle,Ghinet, Alina
, p. 479 - 488 (2016/10/12)
A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c
Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events
Lucescu, Liliana,Ghinet, Alina,Belei, Dalila,Rigo, Beno?t,Dubois, Jo?lle,B?cu, Elena
supporting information, p. 3975 - 3979 (2015/08/24)
Abstract A new family of 3-aroylindolizines bearing a dimethoxytriazine unit in their position 1 was designed, synthesized and evaluated for their ability to inhibit tubulin polymerization and cellular growth in vitro. Compound 39 was the best candidate i
Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase
Dumea, Carmen,Belei, Dalila,Ghinet, Alina,Dubois, Jolle,Farce, Amaury,Bcu, Elena
supporting information, p. 5777 - 5781 (2015/01/08)
The rational structural modification of new substituted indolizin-3-yl(phenyl)methanones 1a-i, 2a-i and 3a-i has greatly improved human farnesyltransferase inhibition. The para-bromophenyl analog 2f bearing an ester unit on the indolizine ring demonstrates the highest inhibition potential, with IC50 value of 1.3 ± 0.2 μM. The amidic series 1a-i proves to be the most promising for future modulations, particularly at the triple bond level.
Synthesis, photophysical, and electrochemical properties of 2,5-diaryl-indolizines
Amaral, M?nica F.Z.J.,Deliberto, Laila A.,De Souza, Camila R.,Naal, Rose M.Z.G.,Naal, Zeki,Clososki, Giuliano C.
, p. 3249 - 3258 (2014/05/06)
A variety of novel 2,5-diaryl-indolizines have been prepared through the palladium-catalyzed cross-coupling reactions of organozinc reagents prepared from 2-aryl-indolizines with aromatic halides. The photophysical properties of representative compounds indicate that the 2,5-diaryl-indolizines are promising candidates to be used in optoelectronic devices and biomolecular labeling. In addition, cyclic voltammetry studies of some nitrophenyl-substituted indolizines have shown evidences of an oxidation process without the correspondent reduction peak suggesting a dimerization reaction.
A Practical Parallel Synthesis of 2-Substituted Indolizines
Chai, Wenying,Kwok, Annette,Wong, Victoria,Carruthers, Nicholas I.,Wu, Jiejun
, p. 2086 - 2088 (2007/10/03)
A practical parallel synthesis of 2-substituted indolizines 4 via phase-separation techniques is reported. Their further transformation into indolizidines 5 is also described.
The Mechanism of Alkylation Reactions. Part 2. The Effect of Pressure and Substituents on the Reaction of Phenacyl Bromide with Pyridine in Methanol
Forster, William,Laird, Robert M.
, p. 1033 - 1044 (2007/10/02)
Rate constants have been determined for the reaction of p-bromophenacyl bromide with pyridine and three substituents pyridines in methanol at 313.2 K.The reaction of phenacyl bromide in methanol at 313.2 K was investigated for pressures up to 100 MPa and the effect of substituents on the volume of activation, ΔV*, determined.From the partial molar volumes of reactants and products, the values of ΔV* were interpreted in terms of the intrinsic volume of the transition state, solvent electrostriction in the transition state and differences in hydrogen bonding between the initial and the transition state.The results support a transition state in which (a) bond forming leads over bond breaking and (b) considerable charge dispersal occurs.A priori calculations of ΔV and ΔV* are compared with experimental values and their utility discussed.
