82748-45-6

Basic information

• Product Name: L-Valine, N-[N-[N-[N-(N-acetyl-L-a-glutamyl)-L-alanyl]-L-tyrosyl]-L-leucyl]-
• CAS NO: 82748-45-6
• Molecular Formula: C30H45N5O10
• Molecular Weight: 635.715
• Mol File: 82748-45-6.mol

Chemical Properties

• CAS DataBase Reference: L-Valine, N-[N-[N-[N-(N-acetyl-L-a-glutamyl)-L-alanyl]-L-tyrosyl]-L-leucyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-[N-[N-[N-(N-acetyl-L-a-glutamyl)-L-alanyl]-L-tyrosyl]-L-leucyl]-(82748-45-6)
• EPA Substance Registry System: L-Valine, N-[N-[N-[N-(N-acetyl-L-a-glutamyl)-L-alanyl]-L-tyrosyl]-L-leucyl]-(82748-45-6)

Safety Data

• Hazardous Substances Data: 82748-45-6(Hazardous Substances Data)

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 13574-13-5 Boc-Glu(OBzl)-OH 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 42538-62-5 caesium (2S)-2-[(tert-butoxycarbonyl)amino]-3-methylbutanoate 

Relevant articles and documents

SOLID PHASE SYNTHESIS OF TYROSINE-CONTAINING HISTONE FRAGMENTS

The solid phase synthesis of Ac-Val-Val-Tyr-Ala-Leu-OH (1), Ac-Glu-Ala-Tyr-Leu-Val-OH (2) and Ac-Leu-Tyr-Gly-Phe-Gly-Gly-OH (3), segments 86-90 of histone H4, 97-101 of histone H3 and 97-102 of histone H4, respectively, is described using chloromethylresin and chloromethyl-Pab-resin as solid supports.In the synthesis of peptides 2 and 3 using 2,6-dichlorobenzyl ether as tyrosine side chain protection, 7percent and 8percent of the 3-dichlorobenzyltyrosine-rearranged peptide could be isolated by Bio-Gel P-2 or diethylaminoethylcellulose chromatography.Alternative use of cyclohexyl ether as tyrosine protection has been explored with satisfactory results.