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82749-70-0

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82749-70-0 Usage

Uses

DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells.

Biological Activity

Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro .

Check Digit Verification of cas no

The CAS Registry Mumber 82749-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,7,4 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 82749-70:
(7*8)+(6*2)+(5*7)+(4*4)+(3*9)+(2*7)+(1*0)=160
160 % 10 = 0
So 82749-70-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H28Cl2O4/c1-2-3-10-22(15-7-4-5-8-15)13-14-12-16(28-11-6-9-17(25)26)19(23)20(24)18(14)21(22)27/h12,15H,2-11,13H2,1H3,(H,25,26)

82749-70-0Downstream Products

82749-70-0Relevant articles and documents

SWELL1-LRRC8 COMPLEX MODULATORS

-

, (2020/12/30)

The present invention is directed to various polycyclic compounds and methods of using these compounds to treat a variety of diseases including metabolic diseases such as obesity, diabetes, nonalcoholic fatty liver disease; cardiovascular diseases such as hypertension and stroke; neurological diseases, male infertility, muscular disorders, and immune disorders.

Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids

Cragoe Jr.,Gould,Woltersdorf Jr.,Ziegler,Bourke,Nelson,Kimelberg,Waldman,Popp,Sedransk

, p. 567 - 579 (2007/10/02)

Blunt and ischemic injuries of the brain have been shown to result in swelling that is predominantly limited to a single cell type, the astrocyte, within the complex cellular mosaic of cerebral gray matter. Evaluation of various diuretic (aryloxy)acetic a

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