82756-19-2 Usage
Uses
Used in Cancer Treatment:
2,4,7-Trimethylbenzo[b]-1,8-naphthyridin-5(10H)-one is used as a therapeutic agent for cancer treatment, specifically targeting the Wnt/β-catenin signaling pathway. This pathway is often dysregulated in various cancers, leading to uncontrolled cell growth and tumorigenesis. By inhibiting tankyrase enzymes, 2,4,7-TRIMETHYLBENZO[B]-1,8-NAPHTHYRIDIN-5(10H)-ONE can help restore normal cellular function and potentially reduce tumor growth.
Used in Stem Cell Research:
In the field of stem cell research, 2,4,7-Trimethylbenzo[b]-1,8-naphthyridin-5(10H)-one is used as a regulatory agent to control stem cell proliferation and differentiation. Its ability to modulate these processes makes it a valuable tool for studying stem cell biology and developing new strategies for stem cell-based therapies.
Used in Diabetes Treatment:
2,4,7-Trimethylbenzo[b]-1,8-naphthyridin-5(10H)-one is being explored as a potential treatment for diabetes. Its role in regulating cellular processes may offer new avenues for managing blood sugar levels and improving overall metabolic health in diabetic patients.
Used in Neurodegenerative Disorder Treatment:
2,4,7-TRIMETHYLBENZO[B]-1,8-NAPHTHYRIDIN-5(10H)-ONE is also being investigated for its potential applications in the treatment of neurodegenerative disorders. The modulation of cellular processes by 2,4,7-Trimethylbenzo[b]-1,8-naphthyridin-5(10H)-one may help slow down the progression of these diseases and improve the quality of life for affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 82756-19-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,7,5 and 6 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 82756-19:
(7*8)+(6*2)+(5*7)+(4*5)+(3*6)+(2*1)+(1*9)=152
152 % 10 = 2
So 82756-19-2 is a valid CAS Registry Number.
82756-19-2Relevant academic research and scientific papers
Reactions of 6-Methyl- and 4,6-Dimethyl-2-arylaminonicotinonitriles with Acids
Shramm, N. I.,Konshin, M. E.
, p. 511 - 514 (2007/10/02)
A substituted nicotinic acid is formed when 6-methyl-2-anilinonicotinonitrile is refluxed with concentrated hydrochloric acid, whereas 4,6-dimethyl-2-anilinonicotinonitrile is not hydrolyzed under these and more severe conditions because of steric hindrance.Both of these nitriles undergo cyclization to 10-aminobenzo-1,8-naphthyridine derivatives under the influence of concentrated sulfuric acid.When 6-methyl-2-arylaminonicotinonitriles are heated in polyphosphoric acid (PPA), they are converted to 2-arylaminonicotinic acid amides and, in part, to benzo-1,8-naphthyrid-10-one derivatives, while 4,6-dimethyl-2-arylaminonicotinonitriles are converted primarily to 10-aminobenzo-1,8-naphthyridines.
