82756-19-2 Usage
General Description
2,4,7-Trimethylbenzo[b]-1,8-naphthyridin-5(10H)-one, also known as XAV-939, is a potent and selective small molecule inhibitor of tankyrase enzymes. 2,4,7-TRIMETHYLBENZO[B]-1,8-NAPHTHYRIDIN-5(10H)-ONE has been extensively studied for its potential therapeutic applications in cancer treatment, particularly in the inhibition of the Wnt/β-catenin signaling pathway. Additionally, 2,4,7-Trimethylbenzo[b]-1,8-naphthyridin-5(10H)-one has shown promise in preclinical studies for its ability to regulate stem cell proliferation and differentiation, as well as its potential role in the treatment of other diseases such as diabetes and neurodegenerative disorders. Overall, this chemical compound has generated considerable interest in the scientific and medical communities for its potential use in targeted therapies and further research is ongoing to uncover its full range of biological activities and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 82756-19-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,7,5 and 6 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 82756-19:
(7*8)+(6*2)+(5*7)+(4*5)+(3*6)+(2*1)+(1*9)=152
152 % 10 = 2
So 82756-19-2 is a valid CAS Registry Number.
82756-19-2Relevant articles and documents
Reactions of 6-Methyl- and 4,6-Dimethyl-2-arylaminonicotinonitriles with Acids
Shramm, N. I.,Konshin, M. E.
, p. 511 - 514 (2007/10/02)
A substituted nicotinic acid is formed when 6-methyl-2-anilinonicotinonitrile is refluxed with concentrated hydrochloric acid, whereas 4,6-dimethyl-2-anilinonicotinonitrile is not hydrolyzed under these and more severe conditions because of steric hindrance.Both of these nitriles undergo cyclization to 10-aminobenzo-1,8-naphthyridine derivatives under the influence of concentrated sulfuric acid.When 6-methyl-2-arylaminonicotinonitriles are heated in polyphosphoric acid (PPA), they are converted to 2-arylaminonicotinic acid amides and, in part, to benzo-1,8-naphthyrid-10-one derivatives, while 4,6-dimethyl-2-arylaminonicotinonitriles are converted primarily to 10-aminobenzo-1,8-naphthyridines.
