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3-TrifluoroMethoxy-pyridin-4-ylaMine, also known as TFPyA, is a pyridine derivative with the molecular formula C6H5F3N2O. It features a trifluoromethoxy group attached to the 3-position of the pyridine ring, endowing it with unique chemical and biological properties. TFPyA is recognized for its role as a building block in the synthesis of pharmaceuticals, agrochemicals, and materials science, and has demonstrated biological activity as a histamine H4 receptor antagonist, positioning it as a potential therapeutic agent for allergic diseases. Furthermore, its fluorogenic properties have made it a valuable component in the development of fluorescent probes for imaging studies.

827586-90-3

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827586-90-3 Usage

Uses

Used in Pharmaceutical Industry:
3-TrifluoroMethoxy-pyridin-4-ylaMine is used as a building block for the synthesis of various pharmaceutical compounds due to its versatile chemical structure and potential to modulate biological activity.
Used in Agrochemical Industry:
TFPyA is utilized as a component in the development of agrochemicals, leveraging its chemical properties to enhance the effectiveness of these products in agricultural applications.
Used in Materials Science:
3-TrifluoroMethoxy-pyridin-4-ylaMine is employed in the creation of new materials, capitalizing on its unique properties to improve material characteristics for specific uses.
Used in Allergy Treatment:
TFPyA is used as a histamine H4 receptor antagonist for the potential treatment of allergic diseases, offering a new avenue for therapeutic intervention in conditions mediated by histamine receptors.
Used in Fluorescent Probe Development:
3-TrifluoroMethoxy-pyridin-4-ylaMine is used as a component in the development of fluorescent probes for imaging studies, taking advantage of its fluorogenic properties to enhance visualization in research and diagnostic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 827586-90-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,7,5,8 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 827586-90:
(8*8)+(7*2)+(6*7)+(5*5)+(4*8)+(3*6)+(2*9)+(1*0)=213
213 % 10 = 3
So 827586-90-3 is a valid CAS Registry Number.

827586-90-3Downstream Products

827586-90-3Relevant academic research and scientific papers

METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES

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Page/Page column 33-34, (2010/04/28)

The present invention pertains to a process for the preparation of functionalized trihalomethoxypyridines of formula (I) comprising reacting hydroxypyridines with thiophosgene in the presence of a base; reacting the obtained chlorothionoformiates with elemental chlorine and finally converting trichloromethoxy pyridines to trihalomethoxy pyridines using a fluoride source.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

Manteau, Baptiste,Genix, Pierre,Brelot, Lydia,Vors, Jean-Pierre,Pazenok, Sergiy,Giornal, Florence,Leuenberger, Charlotte,Leroux, Frederic R.

experimental part, p. 6043 - 6066 (2011/02/26)

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.

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