82760-79-0Relevant articles and documents
Inhibitors of Glycolic Acid Oxidase. 4-Substituted 2,4-Dioxobutanoic Acid Derivatives
Williams, H. W. R.,Eichler, E.,Randall, W. C.,Rooney, C. S.,Cragoe, E. J.,et al.
, p. 1196 - 1200 (2007/10/02)
Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized.These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase.The I50 value of the two most potent representatives, 4-(4'-bromo-4-yl)-2,4-dioxobutanoic acid (8) and 4-thio>-4-yl>-2,4-dioxobutanoic acid (13) is 6 * 10-8 M.
2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
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, (2008/06/13)
2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: STR1 where R is hydrogen or C1-4 alkyl; and L is a lipophilic group consisting essentially of: STR2 where R1 and R2 are each independently selected from the group consisting of (a) hydrogen; (b) C4-12 straight or branched chain alkyl; (c) C4-7 cycloalkyl; and (d) tetrahydronaphthyl; provided that R1 and R2 may not both be hydrogen; and when one of R1 or R2 is tetrahydronaphthyl, the other must be some other substituent; and that positions 2 and 6 of the substituted phenyl moiety may not be substituted; and STR3 where R1, and R2 have the same meaning as above except tetrahydronaphthyl; R3 is bromine, chlorine, or fluorine; m is 0 to 3; or a pharmaceutically acceptable salt thereof.
