827607-22-7Relevant academic research and scientific papers
Synthesis and transformations of 2-R-5-aryl-5,6-dihydro-7H-[1,2,4]- triazolo[5,1-b][1,3]thiazin-7-ones
Britsun,Esipenko,Kudryavtsev,Lozinskii
, p. 232 - 238 (2007/10/03)
A new procedure for preparation of 2-R-5-aryl-5,6-dihydro-7H-[1,2,4] triazolo[5,1-b][1,3]thiazin-7-ones by condensation of 5-R-1,2,4-triazole-3- thiones with 3-arylacryloyl chlorides was developed. The thiazine ring of the [1,2,4]triazolo[5,1-b][1,3]thiazin-7-ones is easily cleaved by treating with ammonia and hydrazine affording amides and hydrazides of 3-aryl-3-(1H-1,2,4- triazol-5-ylsulfanyl)propanoic acids. The latter react with isothiocyanates furnishing carbamoyl thiohydrazides of 3-aryl-3-(1H-1,2,4-triazol-5-ylsulfanyl) propanoic acids that in alkaline media undergo cyclization into 4-aryl-5-[2-(4H-1,2,4-triazol-5-ylsulfanyl)-2-phenylethyl]-2,4-dihydro-3H-1,2, 4-triazole-5-thiones.
