827614-68-6

Basic information

• Product Name: 4-(N-CYCLOPROPYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER
• Synonyms: N-(CYCLOPROPYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZAMIDE;4-(N-CYCLOPROPYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER;N-(Cyclopropyl)-4-(4;4-(Cyclopropylaminocarbonyl)phenylboronic acid, pinacol ester;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(cyclopropylcarbamoyl)phenyl)boronate
• CAS NO: 827614-68-6
• Molecular Formula: C₁₆H₂₂BNO₃
• Molecular Weight: 287.16
• Product Categories: Heterocyclic Compounds
• Mol File: 827614-68-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 212-214°C
• Boiling Point: 444.1 °C at 760 mmHg
• Flash Point: 222.4 °C
• Appearance: /
• Density: 1.11 g/cm³
• Vapor Pressure: 4.4E-08mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(N-CYCLOPROPYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(N-CYCLOPROPYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(827614-68-6)
• EPA Substance Registry System: 4-(N-CYCLOPROPYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(827614-68-6)

Safety Data

• Hazardous Substances Data: 827614-68-6(Hazardous Substances Data)

Usage

General Description

4-(N-Cyclopropylaminocarbonyl)phenylboronic acid, pinacol ester is a complex chemical compound which is often used in organic synthesis, specifically as a reagent or intermediate. 4-(N-CYCLOPROPYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER belongs to the class of organic compounds known as boric acid esters, characterized by the presence of at least one boron-oxygen single bond. It encompasses a boronic acid ester functional group, a cyclopropylamine functional group attached to the carbonyl carbon, and a phenyl ring. This is a highly specific substance that is likely utilized in highly specialized industrial or laboratory settings, particularly in areas relating to the synthesis of pharmaceuticals or other complex organic compounds.

InChI:InChI=1/C16H22BNO3/c1-15(2)16(3,4)21-17(20-15)12-7-5-11(6-8-12)14(19)18-13-9-10-13/h5-8,13H,9-10H2,1-4H3,(H,18,19)

Upstream product

• 765-30-0 Cyclopropylamine 
• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 
• 306745-64-2 4-bromo-N-cyclopropylbenzamide 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 942278-53-7 2-tert-Butoxycarbonylamino-4-(4-cyclopropylcarbamoyl-phenyl)-thiazole-5-carboxylic acid methyl ester 
• 1031746-84-5 (S)-2-[6-(4-cyclopropylcarbamoylphenyl)benzooxazol-2-yl]pyrrolidine-1-carboxylic acid benzyl ester 
• 1031747-15-5 (S)-2-[6-(4-cyclopropylcarbamoyl-phenyl)-1H-imidazo[4,5-b]pyridin-2-yl]pyrrolidine-1-carboxylic acid benzyl ester 
• 1031926-52-9 (S)-2-[6-(4-cyclopropylcarbamoyl-phenyl)-1H-benzoimidazol-2-yl]-2,3-dihydroindole-1-carboxylic acid benzyl ester 
• 1610680-18-6 N-cyclopropyl-4-(4-((4-methoxybenzyl)(2-morpholinoethyl)amino)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide 
• 1610680-20-0 N-cyclopropyl-4-(4-((4-methoxybenzyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide 
• 1610611-38-5 N-(5-cyanopyridin-2-yl)-N-cyclopropyl-3-(4-(cyclopropylcarbamoyl)phenyl)pyrazolo[1,5-a] pyridine-5-carboxamide 
• 1610676-73-7 N-cyclopropyl-4-(7-((2-methoxyethyl)amino)-5-(pyridin-3-yloxy)pyrazolo[1,5-a]pyrimidin-3-yl)benzamide trifluoroacetic acid 
• 1263422-96-3 4-(6-(cyclohexylmethylamino)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide 
• 1361990-92-2 tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate 
• 1263425-70-2 tert-butyl 6-chloro-3-(4-(cyclopropylcarbamoyl)phenyl)imidazo[1,2-b]pyridazin-8-yl((tetrahydro-2H-pyran-4-yl)methyl)carbamate 
• 1263423-93-3 4-(6-(sec-butylamino)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-b]pyridazin-3-yl)-N-cyclopropylbenzamide 
• 1263425-65-5 tert-butyl 6-(sec-butylamino)-3-(4-(cyclopropylcarbamoyl)phenyl)imidazo[1,2-b]pyridazin-8-yl((tetrahydro-2H-pyran-4-yl)methyl)carbamate 
• 1263423-09-1 4-(6-(Cyclohexylamino)-8-(isobutylamino)imidazo[1,2-b]pyridazin-3-yl)-N-cyclopropylbenzamide 

Relevant articles and documents

HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE

This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.

FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION

Provided are a compound represented by general formula (1) and having a TTK inhibitory action and a medicine containing the compound. In formula (1), (X, Y, V, W) is (—N═, ═CR1—, ═N—, —CR7═), (—CR2═, ═N—, ═N—, —CR7═), etc.; A is an (un)substituted aromatic hydrocarbon ring, etc.; L is a single bond, —C(═O)—NRA—, etc.; Z is a group represented by the formula —NR3R4 or a group represented by the formula —OR5; R1 to R3, R6, and R7 each is a hydrogen atom, etc.; R4 and R5 each is an (un)substituted alkyl, etc.; and R8 is an (un)substituted cycloalkyl, etc.

N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS

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